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Brief Title: Study of Talabostat and Pemetrexed vs. Pemetrexed in Stage IIIB/IV Non-Small Cell Lung Cancer (NSCLC) After Failure of Platinum-Based Chemotherapy
Official Title: A Phase 3, Randomized, Double-Blind, Multicenter Study of Talabostat and Pemetrexed vs. Pemetrexed and Placebo in Patients With Advanced (Stage IIIB/IV) Non-Small Cell Lung Cancer (NSCLC) After Failure of Platinum-Based Chemotherapy
Study ID: NCT00290017
Brief Summary: This Phase 3 study will compare the efficacy of talabostat plus pemetrexed to pemetrexed plus placebo in patients with Stage IIIB/IV NSCLC who have failed a platinum-based chemotherapy regimen.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Marshall Schreeder, MD, Huntsville, Alabama, United States
Hematology Oncology Associates, Phoenix, Arizona, United States
Heritage Physician Group-Oncology, Hot Springs, Arkansas, United States
Raul R. Mena, MD, Burbank, California, United States
Pacific Coast Hematology / Oncology Medical Group, Inc., Fountain Valley, California, United States
Robert A. Moss, MD, FACP, Inc., Fountain Valley, California, United States
Antelope Valley Cancer Center, Lancaster, California, United States
Warren Paroly, MD, Oceanside, California, United States
Southwest Cancer Care Medical Group, Poway, California, United States
Mile High Oncology, Denver, Colorado, United States
Medical Specialists of Fairfield, Fairfield, Connecticut, United States
Northwestern Connecticut Oncology Hematology Associates, LLP, Torrington, Connecticut, United States
Lucio Gordan, MD, Gainesville, Florida, United States
Cancer and Blood Disease Center, Lecanto, Florida, United States
Ocala Oncology Center, Ocala, Florida, United States
Cancer Center of Florida, Ocoee, Florida, United States
Northeast Georgia Cancer Care, LLC, Athens, Georgia, United States
North Idaho Cancer Center, Coeur d'Alene, Idaho, United States
Hematology Oncology Associates of Illinois, Chicago, Illinois, United States
Joliet Oncology-Hematology Associates, Joliet, Illinois, United States
American Health Network of Indiana--Hematology/Oncology, Indianapolis, Indiana, United States
Arnett Cancer Center, Lafayette, Indiana, United States
Northern Indiana Oncology Associates, South Bend, Indiana, United States
Associated Physicians and Surgeons, LLC, Terre Haute, Indiana, United States
HUX Cancer Center/Union Hospital, Terre Haute, Indiana, United States
Kansas City Cancer Center, LLC, Overland Park, Kansas, United States
Kentucky Cancer Clinic, Hazard, Kentucky, United States
Mercy Medical Center, Baltimore, Maryland, United States
Chesapeake Oncology Hematology Associates (Tate Center), Glen Burnie, Maryland, United States
Carroll County Cancer Center, Westminster, Maryland, United States
Fallon Clinic, Inc. at Worcester Medical Center, Worcester, Massachusetts, United States
Michael McKenzie, DO, Clinton Township, Michigan, United States
Youssef Hanna, MD, Port Huron, Michigan, United States
Cancer and Transplant Consultants, PLC, Rochester Hills, Michigan, United States
Cancer Care Associates, Rochester Hills, Michigan, United States
Cancer Care Associates, PC, Royal Oak, Michigan, United States
Hematology Oncology Consultants, Royal Oak, Michigan, United States
Jeffrey H. Margolis, MD, Royal Oak, Michigan, United States
William Beaumont Hospital, Royal Oak, Michigan, United States
Dr. Folbe, MD/PC, Troy, Michigan, United States
William Beaumont Hospital, Troy, Michigan, United States
Minnesota Oncology Hematology, PA, Burnsville, Minnesota, United States
Minnesota Oncology Hematology, PA, Minneapolis, Minnesota, United States
St. Joseph Oncology, Inc., St. Joseph, Missouri, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
VA Sierra Nevada Health Care System, Reno, Nevada, United States
Hunterdon Regional Cancer Center, Flemington, New Jersey, United States
Monmouth Medical Center, Long Branch, New Jersey, United States
Hematology Oncology Associates, SJ, PA, Mount Holly, New Jersey, United States
Capital Health System, Trenton, New Jersey, United States
Mercer Bucks Oncology/Hematology, Trenton, New Jersey, United States
New York Oncology Hematology, PC, Albany, New York, United States
Northwestern Carolina Oncology & Hematology, PA, Hickory, North Carolina, United States
Eugene Paschold, MD, Winston Salem, North Carolina, United States
Piedmont Hematology Oncology / Winston-Salem, Winston-Salem, North Carolina, United States
Oncology/Hematology Care, Inc., Cincinnati, Ohio, United States
Dayton Oncology & Hematology, PA, Kettering, Ohio, United States
Cancer Care Associates, Oklahoma City, Oklahoma, United States
Cancer Care Associates, Tulsa, Oklahoma, United States
Satish A. Shah, MD, Gettysburg, Pennsylvania, United States
Medical Oncology Associates of Wyoming Valley, PC, Kingston, Pennsylvania, United States
Hematology-Oncology Group, PC, Langhorne, Pennsylvania, United States
St. Mary Medical Center--Research Center, Langhorne, Pennsylvania, United States
Paoli Hospital, Paoli, Pennsylvania, United States
Rittenhouse Hematology Oncology Associates, Philadelphia, Pennsylvania, United States
Pottstown Memorial Medical Center, Pottstown, Pennsylvania, United States
Bux-Mont Oncology-Hematology, Sellersville, Pennsylvania, United States
Grandview Hospital, Sellersville, Pennsylvania, United States
Cancer Care Institute of Carolina, Aiken, South Carolina, United States
Charleston Hematology Oncology, PA, Charleston, South Carolina, United States
Palmetto Hematology Oncology PC, Spartanburg, South Carolina, United States
Associates in Oncology and Hematology, Chattanooga, Tennessee, United States
McLeod Cancer and Blood Center, Johnson City, Tennessee, United States
University of Tennessee, Knoxville, Tennessee, United States
Texas Cancer Center, Arlington, Texas, United States
Texas Oncology Cancer Center, Austin, Texas, United States
Texas Cancer Center (Dallas Southwest), Dallas, Texas, United States
Mary Crowley Medical Research Center, Dallas, Texas, United States
Texas Cancer Center / Denton, Denton, Texas, United States
El Paso Cancer Treatment Center--East, El Paso, Texas, United States
Texas Oncology, PA, El Paso, Texas, United States
Texas Oncology, PA, Ft. Worth, Texas, United States
US Oncology Research and Clinical Pharmacy, Ft. Worth, Texas, United States
Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States
Texas Oncology, PA, Mesquite, Texas, United States
Texas Oncology, PA / Allison Cancer Center, Midland, Texas, United States
West Texas Cancer Center, Odessa, Texas, United States
Paris Regional Cancer Center, Paris, Texas, United States
Texas Oncology Cancer Center--Sugar Land, Sugar Land, Texas, United States
Tyler Cancer Center, Tyler, Texas, United States
Cancer Outreach Associates, PC / Outreach Clinical Trial Consortium LLC, Abingdon, Virginia, United States
Fairfax Northern Virginia Hematology / Oncology, PC, Fairfax, Virginia, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Virginia Physicians, Inc., Richmond, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Salem, Virginia, United States
Luke Walker, MD, Everett, Washington, United States
Cascade Cancer Center, Kirkland, Washington, United States
Puget Sound Cancer Centers, Seattle, Washington, United States
Cancer Care Northwest, Spokane, Washington, United States
Northwest Cancer Specialists, PC, Vancouver, Washington, United States
Medical Consultants, Ltd., Milwaukee, Wisconsin, United States