Spots Global Cancer Trial Database for A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
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Trial Identification
Brief Title: A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
Official Title: A Randomized, Phase 3, Open-label Study to Evaluate SGN-B6A Compared With Docetaxel in Adult Subjects With Previously Treated Non-small Cell Lung Cancer
Study ID: NCT06012435
Conditions
Study Description
Brief Summary: This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC). Participants in this study must have cancer that has spread through their body or can't be removed with surgery. Participants in this study must have been treated with no more than a platinum-based chemotherapy and an anti-PD-(L)1 drug. Participants with tumors that have certain treatable genomic alterations must have had at least 1 drug for that genomic alteration, in addition to platinum-based chemotherapy. This clinical trial uses an experimental drug called sigvotatug vedotin (SGN-B6A), which is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. This clinical trial also uses a drug called docetaxel. Docetaxel is an anticancer drug that has been approved to treat non-small cell lung cancer. It is usually given to patients who previously received another anticancer treatment. In this study, one group of participants will get sigvotatug vedotin on Days 1 and 15 during each 28-day-cycle. A second group of participants will get docetaxel on Day 1 during each 21-day cycle. This study is being done to see if sigvotatug vedotin works better than docetaxel to treat participants with NSCLC. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Alaska Oncology and Hematology, Anchorage, Alaska, United States
Comprehensive Blood and Cancer Center TRIO, Bakersfield, California, United States
Providence Medical Foundation, Fullerton, California, United States
Cancer and Blood Specialty Clinic, Los Alamitos, California, United States
St. Joseph Hospital Orange, Orange, California, United States
Sansum Clinic, Santa Barbara, California, United States
Rocky Mountain Cancer Centers - Aurora, Lone Tree, Colorado, United States
Cancer Care Centers of Brevard, Inc., Palm Bay, Florida, United States
Illinois Cancer Care, Niles, Illinois, United States
Cancer Center of Kansas, Wichita, Kansas, United States
Maryland Oncology Hematology, P.A., Annapolis, Maryland, United States
Minnesota Oncology Hematology P.A., Minneapolis, Minnesota, United States
Allina Health Cancer Institute, Minneapolis, Minnesota, United States
Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Summit Medical Group, Florham Park, New Jersey, United States
New Mexico Cancer Center, Albuquerque, New Mexico, United States
NYU Langone Hospital, Mineola, New York, United States
NYU Langone Hospital, New York, New York, United States
Oncology Hematology Care, Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
Cleveland Clinic Fairview Hospital, Cleveland, Ohio, United States
Cleveland Clinic, The, Cleveland, Ohio, United States
Cleveland Clinic Hillcrest Hospital, Mayfield Heights, Ohio, United States
Willamette Valley Cancer Institute and Research Center, Eugene, Oregon, United States
Alliance Cancer Specialists, PC, Horsham, Pennsylvania, United States
Texas Oncology, Austin, Texas, United States
Texas Oncology, Odessa, Texas, United States
UT Health East Texas Hope Cancer Center, Tyler, Texas, United States
Texas Oncology, Webster, Texas, United States
Oncology and Hematology Associates of Southwest Virginia, Blacksburg, Virginia, United States
Vista Oncology Inc PS, Olympia, Washington, United States
Northwest Cancer Centers, P.C., Vancouver, Washington, United States
Algemeen Ziekenhuis Klina, Brasschaat, Other, Belgium
Universitair Ziekenhuis Antwerpen, Edegem, Other, Belgium
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika, Olomouc, Other, Czechia
Vseobecna fakultni nemocnice v Praze, Prague, Other, Czechia
Centre Hospitalier de Cholet, Cholet, Other, France
Hopital Bichat-Claude Bernard - APHP, Paris, Other, France
Hospital Center De Cornouaille, Quimper Cedex, Other, France
Centre Hospitalier Universitaire de Rennes, Hopital Pontchaillou, Rennes, Other, France
CHU Toulouse - hopital Larrey, Toulouse, Other, France
University Hospital of Besancon, Besancon Cedex, , France
Klinikum Esslingen GmbH, Esslingen, Other, Germany
Krankenhaus Martha-Maria Halle-Dölau GmbH, Halle, Other, Germany
National Koranyi Institute of Pulmonology, Budapest, Other, Hungary
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Other, Hungary
Azienda Ospedaliera di Rilievo Nazionale Sant'Anna e San Sebastiano, Caserta, Other, Italy
Ospedale San Raffaele, Milano, Other, Italy
Fondazione IRCCS San Gerardo dei Tintori, Monza, Other, Italy
Policlinico Universitario Agostino Gemelli, Roma, Other, Italy
St. Olavs Hospital, Trondheim, Other, Norway
Instytut MSF Sp zoo, Lodz, Other, Poland
Institute of Genetics and Immunology GENIM LCC, Lublin, Other, Poland
Med Polonia Sp. z o. o., Poznan, Other, Poland
Complejo Hospitalario Universitario La Coruna, A Coruna, Other, Spain
Hospital Universitario 12 de Octubre, Madrid, Other, Spain
Hospital Quiron Salud Malaga, Malaga, Other, Spain
Hospital Universitario Son Espases, Palma de Mallorca, Other, Spain
Fundación Instituto Valenciano de Oncología (FIVO), Valencia, Other, Spain
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Other, Spain
Contact Details
Name: Medical Monitor
Affiliation: Seagen Inc.
Role: STUDY_DIRECTOR
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