Spots Global Cancer Trial Database for Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
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Trial Identification
Brief Title: Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
Official Title: A Phase 2, Open-Label, Randomized Trial Evaluating the Impact of Enhanced Versus Standard Dermatologic Management on Selected Dermatologic Adverse Events Among Patients With Locally Advanced or Metastatic EGFR-Mutated NSCLC Treated First-Line With Amivantamab + Lazertinib
Study ID: NCT06120140
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate whether enhanced dermatologic management can reduce incidence of grade greater than or equal to (\>=) 2 dermatologic adverse events of interest (DAEIs) when compared with standard-of-care skin management in participants with locally advanced or metastatic stage IIIB/C-IV epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) treated first-line with amivantamab and lazertinib.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope, Duarte, California, United States
City of Hope Huntington Beach, Huntington Beach, California, United States
City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California, United States
City of Hope Long Beach Elm, Long Beach, California, United States
Cancer and Blood Specialty Clinic, Los Alamitos, California, United States
Keck Hospital of USC, Los Angeles, California, United States
USC Norris Oncology Hematology Newport Beach, Newport Beach, California, United States
City of Hope South Pasadena, South Pasadena, California, United States
Hope and Healing Care, Hinsdale, Illinois, United States
Renown Regional Medical Center, Reno, Nevada, United States
Hunterdon Hematology Oncology, Flemington, New Jersey, United States
Clinical Research Alliance, Inc., Westbury, New York, United States
Valley Medical Center, Renton, Washington, United States
Gundersen Health System, W. Salem, Wisconsin, United States
IADT Instituto Argentino de Diagnostico y Tratamiento, Caba, , Argentina
Centro Medico Austral, Capital Federal, , Argentina
Hospital Privado de la Comunidad, Mar del Plata, , Argentina
Changzhou No 2 Peoples Hospital, Changzhou, , China
West China Hospital, Chengdou, , China
Huizhou Municipal Central Hospital, Huizhou, , China
Hopital Nord, Marseille Cedex 20, , France
Hopital PASTEUR, Nice, , France
Institut Curie, Paris, , France
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, , Germany
Klinikum Kassel GmbH, Kassel, , Germany
Chungbuk National University Hospital, Cheongju-si, , Korea, Republic of
Gachon University Gil Hospital, Incheon, , Korea, Republic of
Severance Hospital Yonsei University Health System, Seoul, , Korea, Republic of
Hospital Pulau Pinang, Georgetown, , Malaysia
University Malaya Medical Centre, Kuala Lumpur, , Malaysia
Hospital Tengku Ampuan Afzan, Kuantan, , Malaysia
Hospital Umum Sarawak, Kuching, , Malaysia
Hosp. Gral. Univ. de Alicante, Alicante, , Spain
Hosp. Univ. Quiron Dexeus, Barcelona, , Spain
Hosp. Univ. Vall D Hebron, Barcelona, , Spain
Hosp. Univ. de Jaen, Jaen, , Spain
Hosp. Univ. Lucus Augusti, Lugo, , Spain
Hosp. Gral. Univ. Gregorio Maranon, Madrid, , Spain
Hosp. Regional Univ. de Malaga, Malaga, , Spain
Hosp. Ntra. Sra. de Valme, Sevilla, , Spain
National Taiwan University Hospital Hsin-Chu Branch, Hsin Chu, , Taiwan
Chang Kung Memorial Hospital, Kaohsiung City, , Taiwan
Taichung Veterans General Hospital, Taichung City, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Linkou Chang Gung Memorial Hospital, Taoyuan City, , Taiwan
Adana City Hospital, Adana, , Turkey
Gulhane Training and Research Hospital, Ankara, , Turkey
Gazi University Hospital, Ankara, , Turkey
Ankara Bilkent City Hospital, Ankara, , Turkey
Ondokuz Mayis University, Samsun, , Turkey
Contact Details
Name: Janssen Research & Development, LLC Clinical Trial
Affiliation: Janssen Research & Development, LLC
Role: STUDY_DIRECTOR
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