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Brief Title: Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine For Advanced Pancreatic Cancer.
Official Title: A Randomized, Double-Blind Phase 3 Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine Plus Placebo For The First-Line Treatment Of Patients With Locally Advanced, Unresectable Or Metastatic Pancreatic Cancer.
Study ID: NCT00471146
Brief Summary: The purpose of this study is to determine whether investigational study drug, AG-013736, and gemcitabine are effective in the first-line treatment of advanced pancreatic cancer.
Detailed Description: This study was prematurely discontinued for futility on 23 January 2009, based on a planned interim analysis by an independent Data Safety Monitoring Board (DSMB) that found no evidence of improvement in the primary endpoint (survival) in patients treated with axitinib and gemcitabine compared to gemcitabine alone. Enrollment on this study has been discontinued.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Pfizer Investigational Site, Antioch, California, United States
Pfizer Investigational Site, Corona, California, United States
Pfizer Investigational Site, Glendora, California, United States
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Pfizer Investigational Site, Clichy cedex, , France
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Pfizer Investigational Site, Montpellier Cedex 02, , France
Pfizer Investigational Site, PARIS Cedex 13, , France
Pfizer Investigational Site, Paris, , France
Pfizer Investigational Site, Pessac Cedex, , France
Pfizer Investigational Site, Rouen, , France
Pfizer Investigational Site, St Herblain Cedex, , France
Pfizer Investigational Site, Berlin, , Germany
Pfizer Investigational Site, Dresden, , Germany
Pfizer Investigational Site, Essen, , Germany
Pfizer Investigational Site, Greifswald, , Germany
Pfizer Investigational Site, Magdeburg, , Germany
Pfizer Investigational Site, Mannheim, , Germany
Pfizer Investigational Site, Muenchen, , Germany
Pfizer Investigational Site, Oldenburg, , Germany
Pfizer Investigational Site, Ulm, , Germany
Pfizer Investigational Site, Shatin, NT, Hong Kong
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Pfizer Investigational Site, Budapest, , Hungary
Pfizer Investigational Site, Budapest, , Hungary
Pfizer Investigational Site, Kaposvar, , Hungary
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Pfizer Investigational Site, Bologna, , Italy
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Pfizer Investigational Site, Milano, , Italy
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Pfizer Investigational Site, Seoul, , Korea, Republic of
Pfizer Investigational Site, Seoul, , Korea, Republic of
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Pfizer Investigational Site, St. Petersburg, , Russian Federation
Pfizer Investigational Site, Singapore, , Singapore
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Pfizer Investigational Site, Cape Town, , South Africa
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Pfizer Investigational Site, Birmingham, , United Kingdom
Pfizer Investigational Site, Edinburgh, , United Kingdom
Pfizer Investigational Site, London, , United Kingdom
Pfizer Investigational Site, London, , United Kingdom
Pfizer Investigational Site, Manchester, , United Kingdom
Pfizer Investigational Site, Southhampton, , United Kingdom
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR