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Spots Global Cancer Trial Database for Combination of Capecitabine and GTI-2040 in the Treatment of Renal Cell Carcinoma

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Trial Identification

Brief Title: Combination of Capecitabine and GTI-2040 in the Treatment of Renal Cell Carcinoma

Official Title: A Phase I/II Study of GTI-2040 and Capecitabine Combination Therapy in Patients With Advanced or Metastatic Renal Cell Carcinoma (mRCC)

Study ID: NCT00056173

Interventions

GTI-2040

Study Description

Brief Summary: This phase II, 43 patient trial, will evaluate the efficacy of GTI-2040, an antisense oligonucleotide complementary to the R2 component of ribonucleotide reductase (RNR) mRNA, in combination with capecitabine, in the setting of advanced/metastatic renal cell carcinoma. Preclinical studies have shown synergy between GTI-2040 and capecitabine against renal cell carcinoma.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Bay Area Cancer Research Group, Concord, California, United States

USC-Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States

CA Hematology Oncology Medical Group, Torrance, California, United States

Innovative Medical Research of South Florida, Inc., Miami Shores, Florida, United States

University of Chicago Medical Center, Chicago, Illinois, United States

Ochsner Clinic Foundation, New Orleans, Louisiana, United States

SUNY Upstate Medical University, Syracuse, New York, United States

Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina, United States

The Cleveland Clinic Foundation, Cleveland, Ohio, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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