Spots Global Cancer Trial Database for Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology
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Trial Identification
Brief Title: Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology
Official Title: Randomized, Open Label, Phase III Trial Of CP- 751,871 In Combination With Paclitaxel And Carboplatin Versus Paclitaxel And Carboplatin In Patients With Non Small Cell Lung Cancer
Study ID: NCT00596830
Study Description
Brief Summary: Determine whether the addition of CP- 751,871 in combination with paclitaxel plus carboplatin prolongs survival in patients with locally advanced (Stage IIIB with pleural effusion) or metastatic (Stage IV or recurrent) NSCLC of non adenocarcinoma histology.
Detailed Description: The study was discontinued on December 29, 2009 due to an analysis by an independent Data Safety Monitoring Committee indicating that the addition of CP-751,871 \[figitumumab\] to paclitaxel plus carboplatin would be unlikely to meet the primary endpoint of improving overall survival compared to paclitaxel plus carboplatin alone. The DSMC recommendation to terminate the trial was based on futility, not on specific safety concerns; however, the DSMC recommended to investigate hyperglycemia as a potential contributor to the morbidity of the patients.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Pfizer Investigational Site, Florence, Alabama, United States
Pfizer Investigational Site, Huntsville, Alabama, United States
Pfizer Investigational Site, Muscle Shoals, Alabama, United States
Pfizer Investigational Site, Phoenix, Arizona, United States
Pfizer Investigational Site, Scottsdale, Arizona, United States
Pfizer Investigational Site, Hot Springs, Arkansas, United States
Pfizer Investigational Site, Aurora, Colorado, United States
Pfizer Investigational Site, Boulder, Colorado, United States
Pfizer Investigational Site, Colorado Springs, Colorado, United States
Pfizer Investigational Site, Colorado Springs, Colorado, United States
Pfizer Investigational Site, Denver, Colorado, United States
Pfizer Investigational Site, Denver, Colorado, United States
Pfizer Investigational Site, Lakewood, Colorado, United States
Pfizer Investigational Site, Littleton, Colorado, United States
Pfizer Investigational Site, Lone Tree, Colorado, United States
Pfizer Investigational Site, Longmont, Colorado, United States
Pfizer Investigational Site, Parker, Colorado, United States
Pfizer Investigational Site, Thornton, Colorado, United States
Pfizer Investigational Site, Norwalk, Connecticut, United States
Pfizer Investigational Site, Norwich, Connecticut, United States
Pfizer Investigational Site, Hudson, Florida, United States
Pfizer Investigational Site, Jacksonville, Florida, United States
Pfizer Investigational Site, Lake City, Florida, United States
Pfizer Investigational Site, Lake City, Florida, United States
Pfizer Investigational Site, Miramar Beach, Florida, United States
Pfizer Investigational Site, New Port Richey, Florida, United States
Pfizer Investigational Site, Orlando, Florida, United States
Pfizer Investigational Site, Orlando, Florida, United States
Pfizer Investigational Site, Pensacola, Florida, United States
Pfizer Investigational Site, Pensacola, Florida, United States
Pfizer Investigational Site, Port St. Lucie, Florida, United States
Pfizer Investigational Site, Spring Hill, Florida, United States
Pfizer Investigational Site, Alpharetta, Georgia, United States
Pfizer Investigational Site, Atlanta, Georgia, United States
Pfizer Investigational Site, Atlanta, Georgia, United States
Pfizer Investigational Site, Atlanta, Georgia, United States
Pfizer Investigational Site, Conyers, Georgia, United States
Pfizer Investigational Site, Cumming, Georgia, United States
Pfizer Investigational Site, Decatur, Georgia, United States
Pfizer Investigational Site, Duluth, Georgia, United States
Pfizer Investigational Site, Lake Spivey, Georgia, United States
Pfizer Investigational Site, Lawrenceville, Georgia, United States
Pfizer Investigational Site, Macon, Georgia, United States
Pfizer Investigational Site, Marietta, Georgia, United States
Pfizer Investigational Site, Snellville, Georgia, United States
Pfizer Investigational Site, Coeur d' Alene, Idaho, United States
Pfizer Investigational Site, Arlington Heights, Illinois, United States
Pfizer Investigational Site, Aurora, Illinois, United States
Pfizer Investigational Site, Chicago, Illinois, United States
Pfizer Investigational Site, Elk Grove Village, Illinois, United States
Pfizer Investigational Site, Galesburg, Illinois, United States
Pfizer Investigational Site, Winfield, Illinois, United States
Pfizer Investigational Site, Yorkville, Illinois, United States
Pfizer Investigational Site, Avon, Indiana, United States
Pfizer Investigational Site, Beech Grove, Indiana, United States
Pfizer Investigational Site, Hobart, Indiana, United States
Pfizer Investigational Site, Hobart, Indiana, United States
Pfizer Investigational Site, Indianapolis, Indiana, United States
Pfizer Investigational Site, Indianapolis, Indiana, United States
Pfizer Investigational Site, Mooresville, Indiana, United States
Pfizer Investigational Site, Mooresville, Indiana, United States
Pfizer Investigational Site, Munster, Indiana, United States
Pfizer Investigational Site, Cedar Rapids, Iowa, United States
Pfizer Investigational Site, Kansas City, Kansas, United States
Pfizer Investigational Site, Overland Park, Kansas, United States
Pfizer Investigational Site, Shawnee Mission, Kansas, United States
Pfizer Investigational Site, Louisville, Kentucky, United States
Pfizer Investigational Site, Louisville, Kentucky, United States
Pfizer Investigational Site, Baltimore, Maryland, United States
Pfizer Investigational Site, Baltimore, Maryland, United States
Pfizer Investigational Site, Lawrence, Massachusetts, United States
Pfizer Investigational Site, Quincy, Massachusetts, United States
Pfizer Investigational Site, Stoneham, Massachusetts, United States
Pfizer Investigational Site, Weymouth, Massachusetts, United States
Pfizer Investigational Site, Worcester, Massachusetts, United States
Pfizer Investigational Site, Detroit, Michigan, United States
Pfizer Investigational Site, Farmington Hills, Michigan, United States
Pfizer Investigational Site, St. Joseph, Michigan, United States
Pfizer Investigational Site, St. Louis Park, Minnesota, United States
Pfizer Investigational Site, Columbus, Mississippi, United States
Pfizer Investigational Site, Corinth, Mississippi, United States
Pfizer Investigational Site, Oxford, Mississippi, United States
Pfizer Investigational Site, Southaven, Mississippi, United States
Pfizer Investigational Site, Tupelo, Mississippi, United States
Pfizer Investigational Site, Kansas City, Missouri, United States
Pfizer Investigational Site, Kansas City, Missouri, United States
Pfizer Investigational Site, Lee's Summit, Missouri, United States
Pfizer Investigational Site, Lincoln, Nebraska, United States
Pfizer Investigational Site, Lincoln, Nebraska, United States
Pfizer Investigational Site, Lincoln, Nebraska, United States
Pfizer Investigational Site, Las Vegas, Nevada, United States
Pfizer Investigational Site, Las Vegas, Nevada, United States
Pfizer Investigational Site, Lebanon, New Hampshire, United States
Pfizer Investigational Site, Manchester, New Hampshire, United States
Pfizer Investigational Site, Lake Success, New York, United States
Pfizer Investigational Site, Manhasset, New York, United States
Pfizer Investigational Site, New Hyde Park, New York, United States
Pfizer Investigational Site, Oneida, New York, United States
Pfizer Investigational Site, Oswego, New York, United States
Pfizer Investigational Site, Syracuse, New York, United States
Pfizer Investigational Site, Syracuse, New York, United States
Pfizer Investigational Site, Burlington, North Carolina, United States
Pfizer Investigational Site, Canton, Ohio, United States
Pfizer Investigational Site, Cleveland, Ohio, United States
Pfizer Investigational Site, Dover, Ohio, United States
Pfizer Investigational Site, Tulsa, Oklahoma, United States
Pfizer Investigational Site, Tulsa, Oklahoma, United States
Pfizer Investigational Site, Tulsa, Oklahoma, United States
Pfizer Investigational Site, Clairton, Pennsylvania, United States
Pfizer Investigational Site, Greensburg, Pennsylvania, United States
Pfizer Investigational Site, Johnstown, Pennsylvania, United States
Pfizer Investigational Site, McKeesport, Pennsylvania, United States
Pfizer Investigational Site, Philadelphia, Pennsylvania, United States
Pfizer Investigational Site, Philadelphia, Pennsylvania, United States
Pfizer Investigational Site, Pittsburgh, Pennsylvania, United States
Pfizer Investigational Site, Pittsburgh, Pennsylvania, United States
Pfizer Investigational Site, Pittsburgh, Pennsylvania, United States
Pfizer Investigational Site, Radnor, Pennsylvania, United States
Pfizer Investigational Site, Sayre, Pennsylvania, United States
Pfizer Investigational Site, Wexford, Pennsylvania, United States
Pfizer Investigational Site, Columbia, South Carolina, United States
Pfizer Investigational Site, Sumter, South Carolina, United States
Pfizer Investigational Site, Bartlett, Tennessee, United States
Pfizer Investigational Site, Knoxville, Tennessee, United States
Pfizer Investigational Site, Knoxville, Tennessee, United States
Pfizer Investigational Site, Knoxville, Tennessee, United States
Pfizer Investigational Site, Maryville, Tennessee, United States
Pfizer Investigational Site, Memphis, Tennessee, United States
Pfizer Investigational Site, Memphis, Tennessee, United States
Pfizer Investigational Site, Austin, Texas, United States
Pfizer Investigational Site, Austin, Texas, United States
Pfizer Investigational Site, Austin, Texas, United States
Pfizer Investigational Site, Austin, Texas, United States
Pfizer Investigational Site, Dallas, Texas, United States
Pfizer Investigational Site, Fort Sam Houston, Texas, United States
Pfizer Investigational Site, Fort Worth, Texas, United States
Pfizer Investigational Site, Fort Worth, Texas, United States
Pfizer Investigational Site, Grapevine, Texas, United States
Pfizer Investigational Site, Houston, Texas, United States
Pfizer Investigational Site, Irving, Texas, United States
Pfizer Investigational Site, Longview, Texas, United States
Pfizer Investigational Site, Plano, Texas, United States
Pfizer Investigational Site, Round Rock, Texas, United States
Pfizer Investigational Site, Round Rock, Texas, United States
Pfizer Investigational Site, San Antonio, Texas, United States
Pfizer Investigational Site, San Marcos, Texas, United States
Pfizer Investigational Site, Tyler, Texas, United States
Pfizer Investigational Site, Bountiful, Utah, United States
Pfizer Investigational Site, Layton, Utah, United States
Pfizer Investigational Site, Murray, Utah, United States
Pfizer Investigational Site, Provo, Utah, United States
Pfizer Investigational Site, Salt Lake City, Utah, United States
Pfizer Investigational Site, Salt Lake City, Utah, United States
Pfizer Investigational Site, West Valley City, Utah, United States
Pfizer Investigational Site, Arlington, Virginia, United States
Pfizer Investigational Site, Christiansburg, Virginia, United States
Pfizer Investigational Site, Fairfax, Virginia, United States
Pfizer Investigational Site, Gainesville, Virginia, United States
Pfizer Investigational Site, Leesburg, Virginia, United States
Pfizer Investigational Site, Roanoke, Virginia, United States
Pfizer Investigational Site, Salem, Virginia, United States
Pfizer Investigational Site, Winchester, Virginia, United States
Pfizer Investigational Site, Woodbridge, Virginia, United States
Pfizer Investigational Site, Wytheville, Virginia, United States
Pfizer Investigational Site, Seattle, Washington, United States
Pfizer Investigational Site, Seattle, Washington, United States
Pfizer Investigational Site, Spokane Valley, Washington, United States
Pfizer Investigational Site, Spokane, Washington, United States
Pfizer Investigational Site, Spokane, Washington, United States
Pfizer Investigational Site, Albury, New South Wales, Australia
Pfizer Investigational Site, Port Macquarie, New South Wales, Australia
Pfizer Investigational Site, Geelong, Victoria, Australia
Pfizer Investigational Site, Wodonga, Victoria, Australia
Pfizer Investigational Site, Linz, , Austria
Pfizer Investigational Site, Wien, , Austria
Pfizer Investigational Site, Rio de Janeiro, RJ, Brazil
Pfizer Investigational Site, Rio de Janeiro, RJ, Brazil
Pfizer Investigational Site, Higienopolis, Sao Paulo/ Brazil, Brazil
Pfizer Investigational Site, Sao Paulo, SP, Brazil
Pfizer Investigational Site, Sao Paulo, SP, Brazil
Pfizer Investigational Site, Sao Paulo, SP, Brazil
Pfizer Investigational Site, Sofia, , Bulgaria
Pfizer Investigational Site, Sofia, , Bulgaria
Pfizer Investigational Site, Sofia, , Bulgaria
Pfizer Investigational Site, Varna, , Bulgaria
Pfizer Investigational Site, Edmonton, Alberta, Canada
Pfizer Investigational Site, Levis, Quebec, Canada
Pfizer Investigational Site, Nova Ves pod Plesi, , Czech Republic
Pfizer Investigational Site, Praha 8, , Czech Republic
Pfizer Investigational Site, Pribram I, , Czech Republic
Pfizer Investigational Site, Pribram V, , Czech Republic
Pfizer Investigational Site, Helsinki, , Finland
Pfizer Investigational Site, Pori, , Finland
Pfizer Investigational Site, Caen Cedex 05, , France
Pfizer Investigational Site, Caen Cedex, , France
Pfizer Investigational Site, Clermond-Ferrand Cedex 01, , France
Pfizer Investigational Site, Dijon, , France
Pfizer Investigational Site, Lyon Cedex 04, , France
Pfizer Investigational Site, Nantes Cedex 2, , France
Pfizer Investigational Site, Rennes Cedex 9, , France
Pfizer Investigational Site, Saint Herblain Cedex, , France
Pfizer Investigational Site, Saint Pierre la Réunion Cedex, , France
Pfizer Investigational Site, Grosshansdorf, , Germany
Pfizer Investigational Site, Karlsruhe, , Germany
Pfizer Investigational Site, Leipzig, , Germany
Pfizer Investigational Site, Mainz, , Germany
Pfizer Investigational Site, Oldenburg, , Germany
Pfizer Investigational Site, Thessaloniki, Pylaia, Greece
Pfizer Investigational Site, Athens, , Greece
Pfizer Investigational Site, Athens, , Greece
Pfizer Investigational Site, Thessaloniki, , Greece
Pfizer Investigational Site, Kowloon, , Hong Kong
Pfizer Investigational Site, Shatin, New Territories, , Hong Kong
Pfizer Investigational Site, Tuen Mun, , Hong Kong
Pfizer Investigational Site, Budapest, , Hungary
Pfizer Investigational Site, Deszk, , Hungary
Pfizer Investigational Site, Szekesfehervar, , Hungary
Pfizer Investigational Site, Szombathely, , Hungary
Pfizer Investigational Site, Torokbalint, , Hungary
Pfizer Investigational Site, Navrangpura / Ahmedabad, Gujarat, India
Pfizer Investigational Site, Bangalore, Karnataka, India
Pfizer Investigational Site, Mumbai, Maharashtra, India
Pfizer Investigational Site, Nagpur, Maharashtra, India
Pfizer Investigational Site, New Delhi, , India
Pfizer Investigational Site, Genova, , Italy
Pfizer Investigational Site, Orbassano (TO), , Italy
Pfizer Investigational Site, Padova, , Italy
Pfizer Investigational Site, Roma, , Italy
Pfizer Investigational Site, Kashiwa, Chiba, Japan
Pfizer Investigational Site, Matsuyama-shi, Ehime, Japan
Pfizer Investigational Site, Gifu-shi, Gifu, Japan
Pfizer Investigational Site, Sapporo-shi, Hokkaido, Japan
Pfizer Investigational Site, Akashi, Hyogo, Japan
Pfizer Investigational Site, Yokohama-city, Kanagawa, Japan
Pfizer Investigational Site, Sakai-shi, Osaka-fu, Japan
Pfizer Investigational Site, Osaka-city, Osaka, Japan
Pfizer Investigational Site, Osakasayama-shi, Osaka, Japan
Pfizer Investigational Site, Chuo-Ku, Tokyo, Japan
Pfizer Investigational Site, Tokyo, , Japan
Pfizer Investigational Site, Gyeonggi-do, , Korea, Republic of
Pfizer Investigational Site, Seoul, , Korea, Republic of
Pfizer Investigational Site, Seoul, , Korea, Republic of
Pfizer Investigational Site, Seoul, , Korea, Republic of
Pfizer Investigational Site, Gdansk, , Poland
Pfizer Investigational Site, Krakow, , Poland
Pfizer Investigational Site, Siedlce, , Poland
Pfizer Investigational Site, Warszawa, , Poland
Pfizer Investigational Site, Warszawa, , Poland
Pfizer Investigational Site, Warszawa, , Poland
Pfizer Investigational Site, Wroclaw, , Poland
Pfizer Investigational Site, Ponce, , Puerto Rico
Pfizer Investigational Site, Moscow, , Russian Federation
Pfizer Investigational Site, Moscow, , Russian Federation
Pfizer Investigational Site, Saint-Petersburg, , Russian Federation
Pfizer Investigational Site, Samara, , Russian Federation
Pfizer Investigational Site, Sochi, , Russian Federation
Pfizer Investigational Site, St-Petersburg, , Russian Federation
Pfizer Investigational Site, St. Petersburg, , Russian Federation
Pfizer Investigational Site, Nitra-Zobor, , Slovakia
Pfizer Investigational Site, Nove Zamky, , Slovakia
Pfizer Investigational Site, Poprad, , Slovakia
Pfizer Investigational Site, L'hospitalet de Llobregat, Barcelona, Spain
Pfizer Investigational Site, Santander, Cantabria, Spain
Pfizer Investigational Site, Pamplona, Navarra, Spain
Pfizer Investigational Site, Cordoba, , Spain
Pfizer Investigational Site, Madrid, , Spain
Pfizer Investigational Site, Valencia, , Spain
Pfizer Investigational Site, Fribourg, , Switzerland
Pfizer Investigational Site, Zuerich, , Switzerland
Pfizer Investigational Site, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
Pfizer Investigational Site, Tainan, , Taiwan
Pfizer Investigational Site, Taipei, , Taiwan
Pfizer Investigational Site, Taipei, , Taiwan
Pfizer Investigational Site, Adana, , Turkey
Pfizer Investigational Site, Ankara, , Turkey
Pfizer Investigational Site, Dnipropetrovsk, , Ukraine
Pfizer Investigational Site, Donetsk, , Ukraine
Pfizer Investigational Site, Kyiv, , Ukraine
Pfizer Investigational Site, Lviv, , Ukraine
Pfizer Investigational Site, Sumy, , Ukraine
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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