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Spots Global Cancer Trial Database for Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer

Official Title: A Phase II Efficacy Trial of Pazopanib in Non-clear Cell Metastatic Renal Cell Cancer (mRCC) PINCR

Study ID: NCT01767636

Study Description

Brief Summary: This phase II trial studies how well pazopanib hydrochloride works in treating patients with kidney cancer that has spread to other places in the body (metastatic). Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Pazopanib hydrochloride may also stop the growth of kidney cancer by blocking blood flow to the tumor.

Detailed Description: PRIMARY OBJECTIVES: I. To determine the efficacy of pazopanib hydrochloride (pazopanib) in non clear cell metastatic renal cell cancer patients as assessed by the overall survival rate at 12 months. SECONDARY OBJECTIVES: I. To determine the rates of best tumor response at the end of the first two treatment cycles of pazopanib in non clear cell metastatic renal cell cancer patients. II. To determine the benefit of pazopanib in increasing progression free survival time. III. To describe toxicity profile of pazopanib in non clear cell metastatic renal cell cancer patients. OUTLINE: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 2 years.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Mayo Clinic in Florida, Jacksonville, Florida, United States

Mayo Clinic, Rochester, Minnesota, United States

Contact Details

Name: Brian Costello, M.D.

Affiliation: Mayo Clinic

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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