Spots Global Cancer Trial Database for Electronic Medical Records and Genomics (eMERGE) Phase III
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Trial Identification
Brief Title: Electronic Medical Records and Genomics (eMERGE) Phase III
Official Title: Electronic Medical Records and Genomics (eMERGE) Phase III
Study ID: NCT03394859
Interventions
Study Description
Brief Summary: The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes. The genetic results will be returned to participants and outcomes tracked through the electronic health records.
Detailed Description: The Electronic Medical Records and Genomics (eMERGE) Network is a National Human Genome Research Institute (NHGRI)-funded consortium tasked with developing methods and best practices for utilization of the electronic medical record (EMR) as a tool for genomic research. Phase III is focused on returning actionable gene variants to patients and measuring clinical outcomes. Ultimately, eMERGE hopes its efforts will result in improvements in health care, through safer and more effective prescription methodology, augmentation of primary and secondary prevention strategies, and enhanced understanding of the biology of disease. eMERGE is composed of 10 clinical sites \[ Childrens Hospital of Pennsylvania (CHOP); Cincinnati Children's Medical Center (CCHMC); Columbia University; Geisinger; Kaiser Permanente Washington with Washington University and the Fred Hutchinson Cancer Research Center; Harvard University; Mayo Clinic; Meharry Medical College; Northwestern University; Vanderbilt University Medical center (VUMC)\], one non clinical site: Marshfield Clinic, two sequencing centers \[Baylor college of Medicine; Partners Healthcare with Broad Institute\], a Coordinating Center (VUMC), and the NHGRI. More information on the eMERGE Network can be found at www.gwas.org. Each sites' research study is tailored to their specific interests. An eMERGE specific sequencing panel was designed and ran on participants covering 109 genes and 1551 Single Nucleotide Variants (SNVs), of which 68 genes and 14 SNVs are clinically actionable and are being returned to patients.
Keywords
Eligibility
Minimum Age: 1 Day
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Contact Details
Name: Teri Manolio, MD, PhD
Affiliation: National Human Genome Research Institute (NHGRI)
Role: PRINCIPAL_INVESTIGATOR
Name: John Harley, MD, PhD
Affiliation: Children's Hospital Medical Center, Cincinnati
Role: PRINCIPAL_INVESTIGATOR
Name: Hakon Hakonarson, MD, PhD
Affiliation: Children's Hospital of Philadelphia
Role: PRINCIPAL_INVESTIGATOR
Name: Chunhua Weng, PhD
Affiliation: Columbia University
Role: PRINCIPAL_INVESTIGATOR
Name: Marc Williams, MD
Affiliation: Geisinger Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Elizabeth Karlson, MD
Affiliation: Harvard University
Role: PRINCIPAL_INVESTIGATOR
Name: Scott Hebbring, PhD
Affiliation: Marshfield Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Iftikhar Kullo, MD
Affiliation: Mayo Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Samuel Adunyah, PhD
Affiliation: Meharry Medical College
Role: PRINCIPAL_INVESTIGATOR
Name: Rex Chisholm, PhD
Affiliation: Northwestern University
Role: PRINCIPAL_INVESTIGATOR
Name: Gail Jarvik, MD, PhD
Affiliation: Kaiser Permanente Washington with the University of Washington and the Fred Hutchinson Cancer Research Center
Role: PRINCIPAL_INVESTIGATOR
Name: Dan Roden, MD
Affiliation: Vanderbilt University Medical Center
Role: PRINCIPAL_INVESTIGATOR
Name: Heidi Rehm, PhD
Affiliation: Partners Healthcare with Broad Institute
Role: PRINCIPAL_INVESTIGATOR
Name: Richard Gibbs, PhD
Affiliation: Baylor College Medicine
Role: PRINCIPAL_INVESTIGATOR
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