Spots Global Cancer Trial Database for In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients

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Trial Identification

Brief Title: In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients

Official Title: In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients

Study ID: NCT00342485

Conditions

Cell Function

Interventions

Study Description

Brief Summary: Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and patients who present with different diseases that involve or implicate the immune system dysregulation (HIV infection, autoimmune diseases and cancer). These PBMC will be studied in vitro for a number of functional parameters, including generating soluable factors that inhibit HIV infection, developing patterns of immune dysregulation, and inducing apoptotic T cell death. The purpose of such studies is to obtain insight into the mechanisms of natural resistance to viral infections, AIDS pathogenesis, and disease-induced immune dysregulation.

Detailed Description: Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and patients who present with different diseases that involve or implicate the immune system dysregulation (HIV infection, autoimmune diseases and cancer). These PBMC will be studied in vitro for a number of functional parameters, including generating soluable factors that inhibit HIV infection, developing patterns of immune dysregulation, and inducing apoptotic T cell death. The purpose of such studies is to obtain insight into the mechanisms of natural resistance to viral infections, AIDS pathogenesis, and disease-induced immune dysregulation.