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Spots Global Cancer Trial Database for MRI and CT Scans to Evaluate Invasive Cervical Cancer Before Treating Patients

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: MRI and CT Scans to Evaluate Invasive Cervical Cancer Before Treating Patients

Official Title: Role of Radiology in the Pretreatment Evaluation of Invasive Cervical Cancer

Study ID: NCT00004936

Conditions

Cervical Cancer

Study Description

Brief Summary: RATIONALE: Imaging procedures such as MRI or CT scans may improve the ability to detect cervical cancer and determine the extent of disease. PURPOSE: Diagnostic trial to determine the effectiveness of MRI and CT scans in evaluating invasive cervical cancer before treatment of patients.

Detailed Description: OBJECTIVES: * Compare the diagnostic performance of magnetic resonance imaging (MRI), computed tomography (CT), and clinical FIGO staging in patients with invasive cervical cancer. * Compare the accuracy of MRI, CT, and clinical FIGO staging in the evaluation of morphologic tumor prognostic factors in FIGO stage IB1 and stage IB2 and greater in these patients. * Examine the value of imaging assessment of tumor prognostic factors (alone or in combination) as predictors of recurrence within 2 years of surgery in these patients. * Evaluate the quality of life in the 12-month period after staging and treatment to potentially change staging accuracy. OUTLINE: This is a multicenter study. Patients undergo a computed tomography scan with iodinated contrast dye followed by a magnetic resonance imaging scan with or without contrast comprising gadopentetate dimeglumine or vice versa. Within 6 weeks of first protocol imaging study, patients undergo one of the following surgeries: * Laparoscopic, transabdominal, or transvaginal hysterectomy * Extrafascial total abdominal hysterectomy * Trachelectomy Quality of life is assessed at 1 and 12 months. Patients are followed every 3 months for 1 year and then every 6 months for 1 year. PROJECTED ACCRUAL: A total of 465 patients will be accrued for this study within 18 months.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Morristown Memorial Hospital, Morristown, New Jersey, United States

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Contact Details

Name: Hedvig Hricak, MD, PhD

Affiliation: Memorial Sloan Kettering Cancer Center

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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