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Brief Title: A Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or Recurrent PD-L1-Positive Cervical Cancer
Official Title: A Phase II, Safety, and Efficacy Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Patients With Metastatic and/or Recurrent PD-L1-Positive Cervical Cancer
Study ID: NCT04300647
Brief Summary: The purpose of this study is to evaluate the efficacy and safety of tiragolumab in combination with atezolizumab and atezolizumab monotherapy in patients with programmed death-ligand 1 (PD-L1)-positive cervical cancer (metastatic and/or recurrent).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Arizona Oncology Associates, Phoenix, Arizona, United States
Kaiser Permanente - Irvine, Irvine, California, United States
Augusta University, Augusta, Georgia, United States
Oncology Associates of Oregon, P.C, Eugene, Oregon, United States
Mater Misericordiae Limited, South Brisbane, Queensland, Australia
Hospital Sao Rafael - HSR, Salvador, BA, Brazil
Hospital Araujo Jorge; Departamento de Ginecologia E Mama, Goiania, GO, Brazil
Hospital de Caridade de Ijui; Oncologia, Ijui, RS, Brazil
Hospital Nossa Senhora da Conceicao, Porto Alegre, RS, Brazil
Hospital Sao Lucas - PUCRS, Porto Alegre, RS, Brazil
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, Sao Paulo, SP, Brazil
Royal Victoria Regional Health Centre, Barrie, Ontario, Canada
Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton, Ontario, Canada
London Regional Cancer Centre, London, Ontario, Canada
Princess Margaret Cancer Center, Toronto, Ontario, Canada
Jewish General Hospital, Montreal, Quebec, Canada
McGill University Health Centre - Glen Site, Montreal, Quebec, Canada
Clinica CIMCA, San José, , Costa Rica
Oncotech S.A., San José, , Costa Rica
ICIMED Instituto de Investigación en Ciencias Médicas, San José, , Costa Rica
Centre Leon Berard, Lyon, , France
Institut Paoli Calmettes, Marseille, , France
Centre Régional de Lutte Contre Le Cancer Val D'aurelle Paul Lamarque, Montpellier, , France
ICO - Site René Gauducheau, Saint Herblain, , France
Gustave Roussy, Villejuif, , France
Istituto Tumori Napoli;Unità Operativa Oncologia Medica Uro-Ginecologica, Napoli, Campania, Italy
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola, Emilia-Romagna, Italy
Policlinico Universitario Agostino Gemelli, Roma, Lazio, Italy
IRCCS S. Raffaele; Ginecologia Oncologica, Milano, Lombardia, Italy
Istituto Europeo Di Oncologia, Milano, Lombardia, Italy
Keimyung University Dongsan Hospital, Daegu, , Korea, Republic of
Korea Cancer Center Hospital of Korea Institute of Radiological and Medical Sciences, Seoul, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Gangnam Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Christus Muguerza Clinica Vidriera, Monterrey, Nuevo LEON, Mexico
Centro Oncológico de Panamá, Panama, , Panama
The Panama Clinic, Panama, , Panama
Clinica Ricardo Palma, San Isidro, , Peru
Bialostockie Centrum Onkologi, Bialystok, , Poland
Szpital Morski im.PCK; Oddzial Onkologii Klinicznej, Oddzial Dzienny, Gdynia, , Poland
Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice; III Klin. Radioter. i Chemioter., Gliwice, , Poland
Wielkopolskie Centrum Onkologii im. M. Sklodowskiej-Curie, Poznan, , Poland
Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie;Klinika Ginekologii Onkologicznej, Warszawa, , Poland
FSBI "National Medical Research Center of Oncology N.N. Blokhin?, Moscow, Moskovskaja Oblast, Russian Federation
MEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy, Moscow, Moskovskaja Oblast, Russian Federation
Chelyabisnk regional clinical center for oncology and nuclear medicine, Chelyabinsk, Sverdlovsk, Russian Federation
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic, Kazan, Tatarstan, Russian Federation
Murmansk Regional Clinical Hospital named after P.A. Bayandin, Murmansk, , Russian Federation
Tomsk scientific research institute of oncology SO RAMN, PAD; Pathological, Tomsk, , Russian Federation
Volgograd Regional Clinical Oncology Dispensary, Volgograd, , Russian Federation
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia, A Coruña, LA Coruña, Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Taichung Veterans General Hospital; Obstetrics and Gynecology, Taichung, , Taiwan
National Taiwan University Hospital; Obstetrics & Gynecology, Taipei City, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
Mackay Memorial Hospital; Obstetrics & Gynaecology, Taipei City, , Taiwan
Chang Gung Medical Foundation, Linkou Branch; Gynecologic Oncology, Taoyuan City, , Taiwan
Siriraj Hospital, Mahidol University, Bangkok, , Thailand
Maharaj Nakorn Chiang Mai Hospital; Faculty of Medicine Chiangmai University, Muang, , Thailand
University College London Hospital, London, , United Kingdom
Sarah Cannon Research Institute, London, , United Kingdom
Christie Hospital Nhs Trust; Medical Oncology, Manchester, , United Kingdom
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR