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Brief Title: Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer
Official Title: Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer: a Prospective, Randomized, Multicenter Study
Study ID: NCT04974346
Brief Summary: Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur. The aim of this trial was to investigate whether para-aortic prophylactic radiotherapy improves disease-free survival in patients with positive pelvic lymph nodes below the common iliac artery.
Detailed Description: This clinical trial enrolled participants with locally advanced cervical cancer with positive pelvic lymph nodes below the common iliac region diagnosed by Positron emission tomography-computed tomography(PET-CT). Participants should be able to receive concurrent cisplatin chemotherapy. No anti-tumor treatment was given before randomization. Participants will be randomly assigned to two groups. The study group will receive radiotherapy of pelvic and para-aorta, concurrent chemotherapy and brachytherapy, and the control group will receive pelvic radiotherapy, concurrent chemotherapy and brachytherapy.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, , China
Jinhua Municipal Central Hospital Medical Group, Jinhua, , China
Lishui People's Hospital, Lishui, , China
Ningbo First Hospital, Ningbo, , China
Taizhou Central Hospiatl, Taizhou, , China
Chongqing University Three Gorges Hospital, Wanzhou, , China