Spots Global Cancer Trial Database for Diaphragm Structure and Function in Childhood Cancer Survivors

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Trial Identification

Brief Title: Diaphragm Structure and Function in Childhood Cancer Survivors

Official Title: Understanding the Influence of Diaphragm Structure and Function on the Control of Breathing During Exercise in Childhood Cancer Survivors (2373GCCC)

Study ID: NCT06205251

Conditions

Childhood Cancer

Cancer Survivors

Interventions

POWERbreathe Plus IMT

Study Description

Brief Summary: The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.

Detailed Description: During the first study visit, participants will undergo a series of pulmonary function and muscle performance tests followed by treadmill walking trials at different speeds with concurrent expired gas analysis via a face mask. The participants will then perform a training program for the breathing muscles at home for 6 weeks. The research team will follow up each week via telehealth visits to support training. After the 6-week training program, participants will return in-person for a follow-up visit and will undergo the same series of assessments as the first visit.