Spots Global Cancer Trial Database for Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
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Trial Identification
Brief Title: Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
Official Title: DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood
Study ID: NCT01572467
Study Description
Brief Summary: RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.
Detailed Description: OBJECTIVES: * To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors. OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: Dana A. Hill, MD
Affiliation: Children's National Research Institute
Role: PRINCIPAL_INVESTIGATOR
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