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Brief Title: Prospective Group-Matched Study With Belzupacap Sarotalocan (Bel-sar; AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)
Official Title: A Prospective Group-Matched Study of Visual Outcomes in Subjects Treated With Belzupacap Sarotalocan (AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)
Study ID: NCT05266430
Brief Summary: This is a prospective multicenter, group-matched study of patients with primary indeterminate lesions or choroidal melanoma who receive treatment with belzupacap sarotalocan (bel-sar; AU-011) and patients who are planned to receive standard of care (SOC) treatment with plaque radiotherapy (plaque) to compare the visual outcomes of AU-011 and plaque radiotherapy.
Detailed Description: Up to approximately 45 patients who are planned to receive plaque radiotherapy for the treatment of IL/CM based on the expert judgment of the Investigator are planned to be enrolled.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Associated Retinal Consultants, P.C., Royal Oak, Michigan, United States
Oregon Health & Science University Casey Eye Institute, Portland, Oregon, United States
Retina Consultants of Carolina, PA, Greenville, South Carolina, United States
St. Thomas Health/Tennessee Retina, P.C., Nashville, Tennessee, United States
Retina Consultants of Texas, Bellaire, Texas, United States
Texas Retina Associates, Dallas, Texas, United States
University of Wisconsin Dept of Ophthalmology & Visual Sciences, Madison, Wisconsin, United States
Name: Medical Monitor
Affiliation: Aura Biosciences, Inc.
Role: STUDY_DIRECTOR