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Brief Title: Study of Weekly Motexafin Gadolinium (MGd) for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Official Title: Phase I/II Trial of Weekly Motexafin Gadolinium (MGd) for Patients With Refractory or Relapsed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Study ID: NCT00290004
Brief Summary: The primary purpose of this study is to evaluate the safety, toxicities, dosage and response rate for an investigational drug, motexafin gadolinium, administered to patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. The secondary purpose of this study is to evaluate the clinical benefit rate, the time it takes for a patient's chronic lymphocytic leukemia or small lymphocytic lymphoma to worsen, the duration of response and the time during which patients survive without chronic lymphocytic leukemia or small lymphocytic lymphoma worsening. Additionally, the patient's response to motexafin gadolinium will be compared to the response of the patient's cells in a laboratory to motexafin gadolinium.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
USC Norris Cancer Hospital, Los Angeles, California, United States
Scripps Cancer Center, San Diego, California, United States
Northwestern University, Chicago, Illinois, United States
The Mayo Clinic, Rochester, Minnesota, United States
Name: Andrew Evens, DO
Affiliation: Robert H Lurie Comprehensive Cancer Center of Northwestern University
Role: PRINCIPAL_INVESTIGATOR
Name: Neil E Kay, MD
Affiliation: Mayo Clinic
Role: PRINCIPAL_INVESTIGATOR