Spots Global Cancer Trial Database for Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
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Trial Identification
Brief Title: Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
Official Title: Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
Study ID: NCT01346020
Conditions
Interventions
Study Description
Brief Summary: This study aims to characterize clonal evolution in chronic lymphocytic leukemia (CLL) using different approaches and to identify a possible association with disease progression, i.e. therapy initiation. 1. Samples This monocentric study is carried out using representative bioarchived leukemic samples with a diagnosis of CLL, either at diagnosis or at evolution. These bioarchived samples were collected locally at our center during years of diagnostic activity, and were accurately pathologically, cytogenetically and molecularly characterized. 2. Clinical data The clinical data were retrospectively collected through collaboration with the referring physicians. 3. Methods Samples will be investigated by means of (1) conventional cytogenetics, (2) fluorescence in situ hybridization (FISH) and (3) SNP-arrays. After analysis of the array data sets, significant results will be validated and in addition, results will be correlated with clinical data.
Detailed Description:
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of human genetics, University Hospital Leuven, Leuven, , Belgium
Contact Details
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