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Brief Title: Observational Study in CLL Patients Receiving BR
Official Title: Observational Study in Comorbid Patients With Chronic Lymphocytic Leukemia Receiving First-line Bendamustine With Rituximab
Study ID: NCT02381899
Brief Summary: The purpose of this observational study is to provide additional data to confirm the safety profile and efficacy of bendamustine and rituximab (BR) chemotherapy for chronic lymphocytic leukemia patients with significant comorbidities treated in routine clinical practice.
Detailed Description: BR (bendamustine, rituximab) combination is currently accepted as a first-line treatment of chronic lymphocytic leukemia (CLL) in patients for whom fludarabine combination chemotherapy is not appropriate. The objective of this observational study is to provide additional data to confirm the safety profile and efficacy of BR for CLL patients treated in routine clinical practice. Specific data of interest are: comorbid conditions, CLL characteristics, adverse events, reasons for discontinuation BR, overall response rates, complete response rate, progression-free survival, overall survival.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Department of Hematology - Oncology, University Hospital, Brno, , Czechia
4th Department of Medicine - Hematology, University Hospital, Hradec Kralove, , Czechia
Department of Hematology, University Hospital, Plzen, , Czechia
Department of Medicine - Hematology, University Hospital Kralovske Vinohrady, Praha, , Czechia
1st Department of Medicine - Hematology, General University Hospital, Praha, , Czechia
Name: Martin Spacek, MD, PhD
Affiliation: Czech CLL Study Group
Role: STUDY_CHAIR