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Spots Global Cancer Trial Database for Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia

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Trial Identification

Brief Title: Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia

Official Title: Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia

Study ID: NCT05246345

Interventions

Study Description

Brief Summary: The purpose of this study is to collect medical informations and samples from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.

Detailed Description: The purpose of this study is to collect medical informations and samples (blood, bone marrow and/or lymph node) from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms (BCL2 mutations, over-expression of other members of the BCL2 protein family and energy metabolism changes).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CHU d'Amiens, Amiens, , France

CHU de Besançon, Besançon, , France

Hopital AVICENNE, Bobigny, , France

CHU clermont-ferrand, Clermont-Ferrand, , France

CHU de Clermont Ferrand, Clermont-Ferrand, , France

CHU Grenoble, Grenoble, , France

CHRU de Lille, Lille, , France

Centre LEON BERARD, Lyon, , France

CHU de Montpellier, Montpellier, , France

CHU Nancy, Nancy, , France

Hopital Pitié Salpetrière, Paris, , France

Hopital Haut LEVEQUE, Pessac, , France

CHU de Reims, Reims, , France

IUCT Oncopole, Toulouse, , France

Contact Details

Name: Romain GUIEZE

Affiliation: University Hospital, Clermont-Ferrand

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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