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Brief Title: Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia
Official Title: Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia
Study ID: NCT05246345
Brief Summary: The purpose of this study is to collect medical informations and samples from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.
Detailed Description: The purpose of this study is to collect medical informations and samples (blood, bone marrow and/or lymph node) from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms (BCL2 mutations, over-expression of other members of the BCL2 protein family and energy metabolism changes).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU d'Amiens, Amiens, , France
CHU de Besançon, Besançon, , France
Hopital AVICENNE, Bobigny, , France
CHU clermont-ferrand, Clermont-Ferrand, , France
CHU de Clermont Ferrand, Clermont-Ferrand, , France
CHU Grenoble, Grenoble, , France
CHRU de Lille, Lille, , France
Centre LEON BERARD, Lyon, , France
CHU de Montpellier, Montpellier, , France
CHU Nancy, Nancy, , France
Hopital Pitié Salpetrière, Paris, , France
Hopital Haut LEVEQUE, Pessac, , France
CHU de Reims, Reims, , France
IUCT Oncopole, Toulouse, , France
Name: Romain GUIEZE
Affiliation: University Hospital, Clermont-Ferrand
Role: PRINCIPAL_INVESTIGATOR