Spots Global Cancer Trial Database for Study of BGB-10188 as Monotherapy, and in Combination With Zanubrutinib, and Tislelizumab
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Trial Identification
Brief Title: Study of BGB-10188 as Monotherapy, and in Combination With Zanubrutinib, and Tislelizumab
Official Title: A Phase 1/2, Dose Escalation and Expansion Study of BGB-10188, a Phosphatidylinositol 3-Kinase Delta (PI3Kδ) Inhibitor, Combined With Zanubrutinib in Patients With Mature B-Cell Malignancies and Combined With Tislelizumab in Patients With Solid Tumors
Study ID: NCT04282018
Study Description
Brief Summary: The purpose of this study is to determine the maximum tolerated dose (MTD), recommended dose for expansion (RDFE), safety and tolerability of BGB-10188 as monotherapy in participants with relapsed/refractory (R/R) mature B-cell malignancies; in combination with zanubrutinib in participants with R/R follicular lymphoma (FL), R/R mantle cell lymphoma (MCL) or R/R diffuse large B-cell lymphoma (DLBCL); and in combination with tislelizumab in participants with advanced solid tumors.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Blacktown Cancer and Haematology Centre, Blacktown, New South Wales, Australia
Saint Vincents Hospital Sydney, Darlinghurst, New South Wales, Australia
Pindara Private Hospital, Benowa, Queensland, Australia
Gallipoli Medical Research Foundation, Greenslopes, Queensland, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Monash Health, Clayton, Victoria, Australia
Perth Blood Institute, West Perth, Western Australia, Australia
Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
The First Hospital of Jilin University, Changchun, Jilin, China
Jining No Peoples Hospital, Jining, Shandong, China
Contact Details
Name: Study Director
Affiliation: BeiGene
Role: STUDY_DIRECTOR
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