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Spots Global Cancer Trial Database for Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies

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Trial Identification

Brief Title: Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies

Official Title: A Phase 2, Open-Label Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacodynamics of GS-9973 in Subjects With Relapsed or Refractory Hematologic Malignancies

Study ID: NCT01799889

Study Description

Brief Summary: The primary objective of the study is to evaluate efficacy of entospletinib in participants with relapsed or refractory hematologic malignancies. Participants with the following relapsed or refractory hematologic malignancies will be enrolled into the study: relapsed or refractory chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), or non-FL indolent non-Hodgkin lymphomas (iNHL; including lymphoplasmacytoid lymphoma/ Waldenström macroglobulinemia \[LPL/WM\], small lymphocytic lymphoma \[SLL\], or marginal zone lymphoma \[MZL\]).

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham, Birmingham, Alabama, United States

Arizona Oncology Associates, Tucson, Arizona, United States

City of Hope National Medical Center, Duarte, California, United States

Sharp Memorial Hospital, San Diego, California, United States

Rocky Mountain Cancer Centers, LLP, Boulder, Colorado, United States

Kaiser Permanente of Colorado, Denver, Colorado, United States

Cancer Center of Central Connecticut, Southington, Connecticut, United States

Florida Cancer - Colonial, Fort Myers, Florida, United States

Memorial Cancer Institute, Hollywood, Florida, United States

Ocala Oncology Center, Ocala, Florida, United States

Northside Hospital, Atlanta, Georgia, United States

Gwinnett Hospital System Dba The Center for Cancer Care, Lawrenceville, Georgia, United States

Northwest Georgia Oncology Center, Marietta, Georgia, United States

University of Chicago, Chicago, Illinois, United States

Illinois Cancer Specialists, Niles, Illinois, United States

Indiana University Simon Cancer Center, Indianapolis, Indiana, United States

Hematology Oncology Clinic, PLLC, Baton Rouge, Louisiana, United States

Tufts Medical Center, Boston, Massachusetts, United States

University of Michigan Health System, Ann Arbor, Michigan, United States

Karmanos Cancer Institute, Detroit, Michigan, United States

Minnesota Oncology Hematology, PA, Minneapolis, Minnesota, United States

Hattiesburg Clinic, Hattiesburg, Mississippi, United States

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha, Nebraska, United States

One Medical Center Drive, Lebanon, New Hampshire, United States

Summit Medical Group, P.A., Florham Park, New Jersey, United States

Clinical Research Alliance, New York, New York, United States

University of North Carolina, Chapel Hill, North Carolina, United States

Gabrail Cancer Center Research, Canton, Ohio, United States

Oncology Hematology Care, Cincinnati, Ohio, United States

Cleveland Clinic, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Williamette Valley Cancer Center and Research Institute, Springfield, Oregon, United States

Prairie Lakes Health Care System, Inc., Watertown, South Dakota, United States

Jones Clinic PC, Germantown, Tennessee, United States

Tennessee Oncology, PLLC, Nashville, Tennessee, United States

Texas Oncology-Austin Midtown, Austin, Texas, United States

Texas Oncology-Medical City Dallas, Dallas, Texas, United States

Center for Cancer and Blood Disorders, Fort Worth, Texas, United States

Cancer Care Network of South Texas, San Antonio, Texas, United States

Cancer Care Center of South Texas, San Antonio, Texas, United States

Virginia Cancer Specialists, PC, Fairfax, Virginia, United States

Virginia Cancer Institute, Richmond, Virginia, United States

Columbia Basin Hematology and Oncology, Kennewick, Washington, United States

University of Washington, Seattle, Washington, United States

Northwest Cancer Specialists, PC, Vancouver, Washington, United States

Yakima Valley Memorial Hospital North Star Lodge, Yakima, Washington, United States

Royal Victoria Regional Health Centre, Barrie, Ontario, Canada

Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada

Contact Details

Name: Gilead Study Director

Affiliation: Gilead Sciences

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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