Spots Global Cancer Trial Database for Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies
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Trial Identification
Brief Title: Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies
Official Title: A Phase 2, Open-Label Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacodynamics of GS-9973 in Subjects With Relapsed or Refractory Hematologic Malignancies
Study ID: NCT01799889
Study Description
Brief Summary: The primary objective of the study is to evaluate efficacy of entospletinib in participants with relapsed or refractory hematologic malignancies. Participants with the following relapsed or refractory hematologic malignancies will be enrolled into the study: relapsed or refractory chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), or non-FL indolent non-Hodgkin lymphomas (iNHL; including lymphoplasmacytoid lymphoma/ Waldenström macroglobulinemia \[LPL/WM\], small lymphocytic lymphoma \[SLL\], or marginal zone lymphoma \[MZL\]).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
Arizona Oncology Associates, Tucson, Arizona, United States
City of Hope National Medical Center, Duarte, California, United States
Sharp Memorial Hospital, San Diego, California, United States
Rocky Mountain Cancer Centers, LLP, Boulder, Colorado, United States
Kaiser Permanente of Colorado, Denver, Colorado, United States
Cancer Center of Central Connecticut, Southington, Connecticut, United States
Florida Cancer - Colonial, Fort Myers, Florida, United States
Memorial Cancer Institute, Hollywood, Florida, United States
Ocala Oncology Center, Ocala, Florida, United States
Northside Hospital, Atlanta, Georgia, United States
Gwinnett Hospital System Dba The Center for Cancer Care, Lawrenceville, Georgia, United States
Northwest Georgia Oncology Center, Marietta, Georgia, United States
University of Chicago, Chicago, Illinois, United States
Illinois Cancer Specialists, Niles, Illinois, United States
Indiana University Simon Cancer Center, Indianapolis, Indiana, United States
Hematology Oncology Clinic, PLLC, Baton Rouge, Louisiana, United States
Tufts Medical Center, Boston, Massachusetts, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Minnesota Oncology Hematology, PA, Minneapolis, Minnesota, United States
Hattiesburg Clinic, Hattiesburg, Mississippi, United States
Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha, Nebraska, United States
One Medical Center Drive, Lebanon, New Hampshire, United States
Summit Medical Group, P.A., Florham Park, New Jersey, United States
Clinical Research Alliance, New York, New York, United States
University of North Carolina, Chapel Hill, North Carolina, United States
Gabrail Cancer Center Research, Canton, Ohio, United States
Oncology Hematology Care, Cincinnati, Ohio, United States
Cleveland Clinic, Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Williamette Valley Cancer Center and Research Institute, Springfield, Oregon, United States
Prairie Lakes Health Care System, Inc., Watertown, South Dakota, United States
Jones Clinic PC, Germantown, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Texas Oncology-Austin Midtown, Austin, Texas, United States
Texas Oncology-Medical City Dallas, Dallas, Texas, United States
Center for Cancer and Blood Disorders, Fort Worth, Texas, United States
Cancer Care Network of South Texas, San Antonio, Texas, United States
Cancer Care Center of South Texas, San Antonio, Texas, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Virginia Cancer Institute, Richmond, Virginia, United States
Columbia Basin Hematology and Oncology, Kennewick, Washington, United States
University of Washington, Seattle, Washington, United States
Northwest Cancer Specialists, PC, Vancouver, Washington, United States
Yakima Valley Memorial Hospital North Star Lodge, Yakima, Washington, United States
Royal Victoria Regional Health Centre, Barrie, Ontario, Canada
Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada
Contact Details
Name: Gilead Study Director
Affiliation: Gilead Sciences
Role: STUDY_DIRECTOR
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