Spots Global Cancer Trial Database for Trial of LAVA-051 in Patients With Relapsed/Refractory CLL, MM, or AML
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Trial Identification
Brief Title: Trial of LAVA-051 in Patients With Relapsed/Refractory CLL, MM, or AML
Official Title: A Phase 1/2a Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of LAVA-051 in Patients With Relapsed or Refractory CLL, MM, or AML
Study ID: NCT04887259
Study Description
Brief Summary: A phase 1/2a, first-in-human trial to evaluate the safety and tolerability of LAVA-051 in patients with relapsed or refractory Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM), or Acute Myeloid Leukemia (AML).
Detailed Description: An open-label, phase 1/2a dose escalation trial with disease-specific expansion cohorts to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary anti-tumor activity of LAVA-051 in patients with relapsed or refractory CLL, MM, or AML.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Emory Winship Cancer Institute, Atlanta, Georgia, United States
NYU Langone Health, New York, New York, United States
Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, United States
Cleveland Clinic, Cleveland, Ohio, United States
MD Anderson Cancer Center, Houston, Texas, United States
CHU Lille, Lille, , France
University Hospital of Nantes, Nantes, , France
Amsterdam UMC, location AMC, Amsterdam, Noord Holland, Netherlands
Amsterdam UMC, location VUmc, Amsterdam, Noord-Holland, Netherlands
Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
University Hospital Vall d'Hebron, Barcelona, , Spain
Cima University of Navarra, Madrid, , Spain
Clinica Universida de Navarra, Pamplona, , Spain
Hospital Clinico Universitario de Salamanca, Salamanca, , Spain
Contact Details
Name: Clinical Trials Management
Affiliation: Lava Therapeutics
Role: STUDY_DIRECTOR
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