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Spots Global Cancer Trial Database for Natural Killer Cells Function in Patients With Chronic Lymphocytic Leukemia

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Trial Identification

Brief Title: Natural Killer Cells Function in Patients With Chronic Lymphocytic Leukemia

Official Title: Study of Natural Killer Cells Function in Untreated Patients With Chronic Lymphocytic Leukemia

Study ID: NCT00934986

Study Description

Brief Summary: Purpose: The involvement of Natural Killer cells (NK) in the efficiency of the treatment in lymphoma and the beginning of new therapies based on function and activation of NK, justify an improvement of knowledge about the status of the population of NK (number, function, genic expression) in Chronic Lymphocytic Leukemia (CLL).

Detailed Description: Method: prospective, monocentric, descriptive study Primary objective: Evaluation of the expression and function of receptors activator of NK cell (KIRs) in patients with CLL at stage A with therapeutic abstention, or stage B or C which require a treatment. Secondary objectives: Measure of the evolution of cytotoxic function of NK cells and theirs biomarkers of activation when the patient receives an immunochemotherapy with Rituximab/ Fludarabine/ Cyclophosphamide (RCF). Verification, by analysis, of functions and biomarkers of the adaptive and innate immunity

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Institut PAOLI-CALMETTES, Marseille, , France

Contact Details

Name: Thérèse AURRAN-SCHLEINITZ, MD

Affiliation: Institut Paoli-Calmettes

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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