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Spots Global Cancer Trial Database for Phase I/II Study of Genasense in Patients With Chronic Lymphocytic Leukemia

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Phase I/II Study of Genasense in Patients With Chronic Lymphocytic Leukemia

Official Title: Phase I-II Multicenter Study of Genasense (Bcl-2 Antisense Oligonucleotide) in Patients With Advanced Chronic Lymphocytic Leukemia

Study ID: NCT00021749

Study Description

Brief Summary: This non-randomized study will test the safety and effectiveness of Genasense in patients with CLL.

Detailed Description: This study is a two-part phase I-II study. Part 1 will determine the MTD of Genasense in patients with CLL. This dose will then be tested in a non-randomized, multi-center, Phase II sequential clinical trial of Genasense used alone for treatment of patients with advanced CLL. Pharmacokinetics of Genasense and kinetics of Bcl-2 down regulation and re-expression in CLL cells will be followed in selected patients.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Long Island Jewish Medical Center, New Hyde Park, New York, United States

MD Anderson Cancer Center, Houston, Texas, United States

San Antonio Cancer Institute, San Antonio, Texas, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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