Spots Global Cancer Trial Database for Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)
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Trial Identification
Brief Title: Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)
Official Title: A Phase 3 Multicentre, Randomized, Prospective, Open-label Trial of Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)
Study ID: NCT04608318
Conditions
Study Description
Brief Summary: The aim of this study is to compare the efficacy of continuous ibrutinib monotherapy with fixed-duration venetoclax plus obinutuzumab and fixed-duration ibrutinib plus venetoclax by measuring progression-free survival (PFS) in patients with previously untreated CLL.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
LKH-Universtitätsklinikum Graz, Graz, , Austria
Landeskrankenhaus - Universitätskliniken Innsbruck, Innsbruck, , Austria
Medizinische Universität Wien, Wien, , Austria
Hanusch Krankenhaus, Wien, , Austria
Wiener Gesundheitsverbund Klinik Ottakring, Wien, , Austria
Algemeen Ziekenhuis St. Jan, Brugge, , Belgium
Universitair Ziekenhuis Leuven, Leuven, , Belgium
Algemeen Ziekenhuis Delta, Roeselare, , Belgium
Aalborg Universitetshospital, Aalborg, , Denmark
Aarhus Universitetshospital, Aarhus, , Denmark
Rigshospitalet, Copenhagen, , Denmark
Sydvestjysk Sygehus Esbjerg, Esbjerg, , Denmark
Regionshospitalet Holstebro, Holstebro, , Denmark
Odense Universitetshospital, Odense, , Denmark
Zealand University Hospital, Roskilde, , Denmark
Lillebaelt Vejle Sygehus, Vejle, , Denmark
Helsinki University Hospital, Helsinki, , Finland
Tampere University Hospital, Tampere, , Finland
Turku University Hospital, Turku, , Finland
Universitätsklinikum Augsburg, Augsburg, , Germany
Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, , Germany
Charite Universitaetsmedizin - Campus Benjamin Franklin, Berlin, , Germany
Helios Klinikum Berlin Buch, Berlin, , Germany
Charite Universitätsmedizin - Campus Virchow Klinikum, Berlin, , Germany
Ev. Diakoniekrankenhaus, Bremen, , Germany
Gemeinschaftspraxis für Hämatologie & Onkologie, Dortmund, , Germany
Gemeinschaftspraxis Hämatologie Onkologie, Dresden, , Germany
Universitätsklinik Carl Gustav Carus, Dresden, , Germany
Sana Krankenhaus Benrath, Düsseldorf, , Germany
St. Georg Klinikum Eisenach, Eisenach, , Germany
ISP Erlangen Onkologische Schwerpunktpraxis, Erlangen, , Germany
Universitätsklinikum Erlangen, Erlangen, , Germany
Universitaetsklinikum Essen, Essen, , Germany
Onkologische Schwerpunktpraxis, Esslingen, , Germany
Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, , Germany
Universitätsklinikum Freiburg, Freiburg, , Germany
Uniklinikum Gießen und Marburg, Gießen, , Germany
MVZ Onkologische Kooperation Harz, Goslar, , Germany
Universitätsklinikum Hamburg-Eppendorf, Hamburg, , Germany
OncoResearch Lerchenfeld, Hamburg, , Germany
Evangelische Krankenhaus Hamm, Hamm, , Germany
Onkologisches Ambulanzzentrum - MediProjekt, Hannover, , Germany
Onkologische Schwerpunktpraxis Heidelberg, Heidelberg, , Germany
Universitätsklinikum Heidelberg, Heidelberg, , Germany
Marien Hospital Herne, Herne, , Germany
Universitätskliniken des Saarlandes, Homburg, , Germany
Universitätsklinikum Jena, Jena, , Germany
Westpfalz-Klinikum GmbH, Kaiserslautern, , Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel, , Germany
Praxis für Haematologie und Onkologie, Koblenz, , Germany
MVZ Hämatologie Onkologie Koblenz, Koblenz, , Germany
Universitätsklinik Köln, Köln, , Germany
H.O.T Onkologie Praxis Landshut, Landshut, , Germany
Universitätsklinikum Leipzig, Leipzig, , Germany
Onkopraxis Probstheida, Leipzig, , Germany
Klinikum Lippe Lemgo, Lemgo, , Germany
St Vincenz Krankenhaus, Limburg, , Germany
Lübecker Onkologische Schwerpunktpraxis, Lübeck, , Germany
Gemeinschaftspraxis Haematologie und Onkologie, Magdeburg, , Germany
Universitätsklinikum Magdeburg, Magdeburg, , Germany
Mannheimer Onkologie Praxis, Mannheim, , Germany
Praxis für Innere Medizin - Hämatologie und Onkologie, Marburg, , Germany
Stauferklinikum Schwäbisch Gmünd, Mutlangen, , Germany
Kliniken Maria Hilf, Mönchengladbach, , Germany
München Klinik Schwabing, München, , Germany
Klinikum der Universitaet München - Grosshadern Campus, München, , Germany
Klinikum rechts der Isar - Technische Universitaet Muenchen, München, , Germany
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster, , Germany
Klinikum Oldenburg, Oldenburg, , Germany
Brüderkrankenhaus St. Josef Paderborn, Paderborn, , Germany
Gemeinschaftspraxis für Hämatologie und Onkologie, Ravensburg, , Germany
Barmherzigen Brüder Krankenhaus, Regensburg, , Germany
Schwerpunktpraxis für Hämatologie & Onkologie - OncoPro GbR, Regensburg, , Germany
Universitätsklinik Rostock, Rostock, , Germany
OnkoSaar Praxis für Hämatologie und Onkologie, Saarbrücken, , Germany
Zentrum für abulante Hämatologie und Onkologie, Siegburg, , Germany
Marienhospital Stuttgart, Stuttgart, , Germany
Robert-Bosch-Krankenhaus, Stuttgart, , Germany
Universitätsklinik Tübingen, Tübingen, , Germany
Universitätsklinikum Ulm, Ulm, , Germany
MVZ Weiden GmbH, Weiden, , Germany
Hämatologisch Onkologische Schwerpunktpraxis, Würzburg, , Germany
Cork University Hospital, Cork, , Ireland
St Vincents University Hospital, Dublin, , Ireland
Mater Misericordiae University Hospital, Dublin, , Ireland
St. James's Hospital, Dublin, , Ireland
Beaumont Hospital, Dublin, , Ireland
University Hospital Galway, Galway, , Ireland
University Hospital Limerick, Limerick, , Ireland
University Hospital Waterford, Waterford, , Ireland
Soroka University Medical Center, Be'er Sheva, , Israel
Shamir Medical Center Assaf Harofeh, Be'er Ya'aqov, , Israel
Bnai-Zion Medical Center, Haifa, , Israel
Hadassah Medical Center Ein Kerem University Hospital, Jerusalem, , Israel
Meir Medical Center, Kfar-Saba, , Israel
Galilee Medical Center, Nahariya, , Israel
Rabin Medical Center Beilinson Hospital, Petach-Tikva, , Israel
Chaim Sheba Medical Center, Ramat Gan, , Israel
Kaplan Medical Center, Rechovot, , Israel
Tel Aviv Sourasky Medical Center, Tel-Aviv, , Israel
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Catania, , Italy
Azienda Ospedaliero Universitaria di Ferrara, Ferrara, , Italy
Ospedale dell'Angelo, Mestre, , Italy
Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milano, , Italy
ASST Grande Ospedale Metropolitano Niguarda, Milano, , Italy
IRCCS Ospedale San Raffaele, Milano, , Italy
Ospedale S. Maria della Misericordia, Perugia, , Italy
Umberto I - Policlinico di Roma - Sapienza Università, Roma, , Italy
Gmelli University Hospital, Roma, , Italy
Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Torino, , Italy
Nordwest Ziekenhuisgroep, Locatie Alkmaar, Alkmaar, , Netherlands
OLVG Amsterdam, Amsterdam, , Netherlands
Amsterdam Universitair Medische Centra, Amsterdam, , Netherlands
Rijnstate, Locatie Arnhem, Arnhem, , Netherlands
Amphia Ziekenhuis, Breda, , Netherlands
Reinier de Graaf Ziekenhuis, Delft, , Netherlands
Slingeland ziekenhuis, Doetinchem, , Netherlands
Albert Schweitzer Ziekenhuis, Dordrecht, , Netherlands
Ziekenhuis Gelderse Vallei, Ede, , Netherlands
Martini Ziekenhuis, Groningen, , Netherlands
Ziekenhuis St Jansdal, Harderwijk, , Netherlands
Medisch Centrum Leeuwarden, Leeuwarden, , Netherlands
Alrijne Ziekenhuis, Leiderdorp, , Netherlands
St. Antonius Ziekenhuis, Nieuwegein, , Netherlands
Canisius-Wilhelmina Ziekenhuis, Nijmegen, , Netherlands
Maasstad Ziekenhuis, Rotterdam, , Netherlands
Jeroen Bosch Ziekenhuis, s-Hertogenbosch, , Netherlands
Franciscus Vlietland, Schiedam, , Netherlands
Ziekenhuis Rivierenland Tiel, Tiel, , Netherlands
Diakonessenhuis, Utrecht, , Netherlands
VieCuri Medish Centrum, Venlo, , Netherlands
Isala Zwolle, Zwolle, , Netherlands
Haukeland University Hospital, Bergen, , Norway
Akershus University Hospital, Lørenskog, , Norway
Oslo University Hospital, Oslo, , Norway
St. Olavs Hospital Trondheim University Hospital, Trondheim, , Norway
Hospital Germans Trias i Pujol, Badalona, , Spain
Vall d'Hebron University Hospital, Barcelona, , Spain
Hospital Clinic de Barcelona, Barcelona, , Spain
Hospital Duran i Reynals, Barcelona, , Spain
Hospital Universitario La Princesa, Madrid, , Spain
Hospital Universitario Infanta Leonor, Madrid, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Hospital Costa del Sol, Málaga, , Spain
Hospital Universitario Central de Asturias, Oviedo, , Spain
Hospital Clinico Universitario de Salamanca, Salamanca, , Spain
Hospital Marques de Valdecilla, Santander, , Spain
Hospital Universitario Virgen de Valme, Sevilla, , Spain
Hospital Clinico Universitario Valencia, Valencia, , Spain
Residencia Sanitaria La Fe - Valencia, Valencia, , Spain
Hospital Clinico Universitario Lozano Blesa, Zaragoza, , Spain
Soedra Aelvsborgs Sjukhus, Borås, , Sweden
Falu Lasarett, Falun, , Sweden
Sahlgrenska University Hospital, Göteborg, , Sweden
Hallands Sjukhus Halmstad, Halmstad, , Sweden
Universitetssjukhuset Linköping, Linköping, , Sweden
Sunderby Hospital, Luleå, , Sweden
Skåne University Hospital, Lund, , Sweden
Karolinska University Hospital Solna, Stockholm, , Sweden
Umeå University Hospital, Umeå, , Sweden
Uppsala University Hospital, Uppsala, , Sweden
Hallands Sjukhus, Varberg, , Sweden
Örebro University Hospital, Örebro, , Sweden
Kantonsspital Aarau, Aarau, , Switzerland
Kantonsspital Baden, Baden, , Switzerland
Universitätsspital Basel, Basel, , Switzerland
Ospedale Regionale Bellinzona e Valli, Bellinzona, , Switzerland
Inselspital Bern, Bern, , Switzerland
Spitalzentrum Oberwallis, Brig, , Switzerland
Kantonsspital Graubünden, Chur, , Switzerland
HFR Fribourg Hôpital cantonal, Fribourg, , Switzerland
Hôpitaux Universitaires Genève, Geneve, , Switzerland
Kantonsspital Baselland, Liestal, , Switzerland
Luzerner Kantonsspital, Luzern, , Switzerland
Spital Thurgau AG - Kantonsspital Münsterlingen, Münsterlingen, , Switzerland
Kantonsspital Olten, Olten, , Switzerland
Kantonsspital St. Gallen, St Gallen, , Switzerland
Spital Thun, Thun, , Switzerland
Kantonsspital Winterthur, Winterthur, , Switzerland
Stadtspital Triemli, Zürich, , Switzerland
Universitätsspital Zuerich, Zürich, , Switzerland
Contact Details
Name: Othman Al-Sawaf, Dr. med.
Affiliation: German CLL Study Group
Role: PRINCIPAL_INVESTIGATOR
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