Infections

Respiratory Tract (Lung and Bronchial) Diseases

Ear, Nose, and Throat Diseases

All Conditions

Neoplasms

Digestive System Diseases

Mouth and Tooth Diseases

Symptoms and General Pathology

Rare Diseases

Sinusitis

Colorectal Neoplasms

Nasopharyngeal Neoplasms

Chronic Disease

Communicable Diseases

Respiratory Tract Infections

Paranasal Sinus Diseases

Nose Diseases

Respiratory Tract Diseases

Otorhinolaryngologic Diseases

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Head and Neck Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Disease Attributes

Chronic Graft Versus Host Disease

Anti-Inflammatory Agents

Respiratory System Agents

All Drugs and Chemicals

Budesonide

Bronchodilator Agents

Anti-Asthmatic Agents

Glucocorticoids

Hormones

Hormone Antagonists

each subject serves as their own control with one nostril being treated with pulmicort and one not

pulmicort

Garrett R Griffin, MD

That high-dose steroid applied to the nasal cavity immediately post-operatively will improve olfaction and healing following endoscopic sinus surgery.

Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis

will be measured with the University of Pennsylvania Smell Identification Test (UPSIT), whose scores range from 0 to 40, where 0 is the inability to smell anything and 40 is perfect smell identification

will be assessed with the Perioperative Sinus Endoscopy score (POSE), a 20 point scale where 0 is no sinus challenges and 20 represents the greatest blockage.

Scored with the University of Pennsylvania Smell Identification Test, whose scores range from 0 to 40, where 0 is the inability to smell anything and 40 is perfect smell identification

Assessed with Perioperative Sinus Endoscopy (POSE) score

American Rhinologic Society

University of Michigan

Resident/Research Fellow

each subject serves as their own control with one nostril being treated with pulmicort and one not

pulmicort: applied to nasal packing after surgery

Single Arm; Nostrils as Experimental and Comparator

Age, Categorical

Sex: Female, Male

Race (NIH/OMB)

United States

Region of Enrollment

This was a pilot study with less enrollment than desired and poor rate of completion with only 5 participants completing the full 24 week trial. This study could be done on a larger/similar scale with some additional useful data obtained.

Garrett Griffin, MD

Treated Nostril (Pulmicort)

Untreated Nostril (no Pulmicort)

Of sixteen participants at the three week mark, one participant's data was unable to be unblinded accurately, and one participant had no UPSIT scores taken, leaving an analysis population of 14,

Olfaction

Placebo Treated Nostril (no Pulmicort)

unblinding could not be done on one person accurately, so only 15 rather than 16 people's data could be analyzed

Sinonasal Health

Placebo/Untreated Nostril (no Pulmicort)

Of six participants remaining at 24 weeks, one participant's data could not be accurately unblinded leaving analysis of 5

Of six participants at 24 weeks, one's data was unable to be unblinded accurately, leaving an analysis population of 5 participants

Overall Study

Spots Global Cancer Trial Database for Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis

Trial Identification

Conditions

Interventions

Study Description

Keywords

Eligibility

Locations

Contact Details

Useful links and downloads for this trial