Spots Global Cancer Trial Database for Prospective Cohort for Early Detection of Liver Cancer

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Trial Identification

Brief Title: Prospective Cohort for Early Detection of Liver Cancer

Official Title: Prospective Cohort for Early Detection of Liver Cancer

Study ID: NCT05541601

Conditions

Cirrhosis

Hepatocellular Carcinoma

Interventions

Blood and Urine samples

Study Description

Brief Summary: This study aims to recruit 3000 people with liver cirrhosis into a Prospective cohort for early detection of Liver cancer - the Pearl cohort. The study team believe that using a combination of novel tests may improve the detection of early Hepatocellular Carcinoma (HCC).

Detailed Description: During a four-year follow-up period, around 100 Pearl patients are expected to be diagnosed with HCC. Blood, urine, clinical and imaging data will be collected over the follow up period. The samples will be used to identify a range of tests (including genetic, protein and other biomarkers), which along with the clinical data will hopefully identify those most at risk of developing HCC, and to identify HCC at the earliest possible time points.