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Spots Global Cancer Trial Database for Adult-to-Adult Living Donor Liver Transplantation Study

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Trial Identification

Brief Title: Adult-to-Adult Living Donor Liver Transplantation Study

Official Title: Adult-to-Adult Living Donor Liver Transplantation Cohort Study

Study ID: NCT00096733

Interventions

Study Description

Brief Summary: There are two principal purposes of this study: 1) to determine whether it is more beneficial for a liver transplant recipient candidate to pursue a living donor liver transplant (LDLT) or wait for a deceased donor liver transplant (DDLT), and 2) to study the impact of liver donation on the donor's health and quality of life.

Detailed Description: Adult to adult living donor liver transplantation (LDLT) is a relatively new procedure increasingly used at major transplantation centers. Relatively small numbers of cases are performed at any one center and approaches to the patient and donor are too diverse across centers to provide reliable and generalizable information on donor and recipient outcomes from individual centers. Therefore, a network of nine leading liver transplantation centers and a data coordination center (DCC) has been organized to accrue and follow sufficient numbers of patients being considered for and undergoing LDLT to provide generalizable results from adequately powered studies. This network has established the Adult to Adult Living Donor Liver Transplantation Cohort Study (A2ALL) that will conduct both retrospective and prospective studies of LDLT. The primary study objective is to analyze the effect of choosing to pursue living liver donation. The principal hypothesis is that pursuit of a living liver allograft leads to decreased pre-transplant morbidity and mortality and better long term outcomes for patients starting from the point at which listed patients have a potential donor evaluated (at least a history and physical examination). Emerging data suggest that LDLT provides an inferior graft because of reduced parenchymal mass and added technical complexity when compared to a whole liver used for DDLT. The magnitude of the disadvantage to the LDLT graft will be assessed by comparing results between LDLT and DDLT from the time of transplant. Finally, a careful and detailed series of studies of potential and actual living liver donors is included as a primary objective because of the tremendous importance of this issue to our understanding of the impact of the procedure. Secondary objectives will address selected biological and clinical issues in transplantation structured around the comparison between DDLT and LDLT.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of California Los Angeles, Los Angeles, California, United States

University of California San Francisco, San Francisco, California, United States

University of Colorado Health System, Denver, Colorado, United States

Northwestern University, Chicago, Illinois, United States

Columbia University, New York, New York, United States

University of North Carolina, Chapel Hill, North Carolina, United States

University of Pennsylvania, Philadelphia, Pennsylvania, United States

University of Virginia, Charlottesville, Virginia, United States

Virginia Commonwealth University, Richmond, Virginia, United States

Contact Details

Name: Robert M Merion, MD

Affiliation: University of Michigan - A2ALL Data Coordinating Center

Role: STUDY_CHAIR

Name: Carl L Berg, MD

Affiliation: University of Virginia Health System

Role: STUDY_CHAIR

Name: Jean Emond, MD

Affiliation: Columbia University

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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