Spots Global Cancer Trial Database for Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
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Trial Identification
Brief Title: Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
Official Title: A Phase 3, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Patients With Previously Untreated Chronic Lymphocytic Leukemia
Study ID: NCT06073821
Conditions
Study Description
Brief Summary: The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)
Detailed Description: Chronic lymphocytic leukemia is a type of blood cancer that affects people around the world. People with CLL suffer from enlarged lymph nodes, spleen, or liver, or have symptoms like night sweats, weight loss and fever. They have shorter life expectancy compared to healthy people. There is an urgent need for new treatment to prolong participant life and control disease-related symptoms. In this study, participants with CLL, without prior treatment will receive either venetoclax plus obinutuzumab combination treatment that is considered a standard first line treatment or receive sonrotoclax plus zanubrutinib. It is hypothesized that sonrotoclax plus zanubrutinib may be better than venetoclax plus obinutuzumab in treating CLL. The main purpose of this study is to compare the duration the participants live without the CLL getting worse between participants who received venetoclax plus obinutuzumab versus sonrotoclax plus zanubrutinib. Approximately 640 participants will be included in this study around the world. Participants will have equal chance to be allocated to receive either of the treatment combinations.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Alaska Oncologyand Hematology, Llc, Anchorage, Alaska, United States
Valkyrie Clinical Trials, Los Angeles, California, United States
Chao Family Comprehensive Cancer Center, Orange, California, United States
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana, United States
Mission Cancer and Blood, Des Moines, Iowa, United States
Norton Cancer Institute Pavilion, Louisville, Kentucky, United States
St Vincent Frontier Cancer Center, Billings, Montana, United States
Clinical Research Alliance, Inc, Westbury, New York, United States
Lumi Research, Kingwood, Texas, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Genesiscare North Shore, St Leonards, New South Wales, Australia
Westmead Hospital, Westmead, New South Wales, Australia
Pindara Private Hospital, Benowa, Queensland, Australia
Sunshine Coast Hospital and Health Service, Birtinya, Queensland, Australia
Princess Alexandra Hospital, Brisbane, Queensland, Australia
Monash Health, Clayton, Victoria, Australia
St Vincents Hospital Melbourne, Fitzroy, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
Cabrini Hospital Malvern, Malvern, Victoria, Australia
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
Fiona Stanley Hospital, Murdoch, Western Australia, Australia
Hollywood Private Hospital, Nedlands, Western Australia, Australia
Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre, Greenfiled Park, Quebec, Canada
Ciusss de Lestrie Chus, Sherbrooke, Quebec, Canada
Chu de Quebec Universite Laval, Quebec, , Canada
Pusan National University Hospital, Busan, Busan Gwang'yeogsi, Korea, Republic of
Seoul National University Bundang Hospital, Seongnamsi, Gyeonggido, Korea, Republic of
Chonnam National University Hwasun Hospital, Hwasungun, Jeonranamdo, Korea, Republic of
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Severance Hospital Yonsei University Health System, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center, Seoul, Seoul Teugbyeolsi, Korea, Republic of
The Catholic University of Korea, Seoul St Marys Hospital, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Auckland City Hospital, Auckland, , New Zealand
Health New Zealand Canterbury, Christchurch, , New Zealand
North Shore Hospital, Takapuna, , New Zealand
Tauranga Hospital, Tauranga, , New Zealand
Wellington Regional Hospital (Ccdhb), Wellington, , New Zealand
Auxilio Mutuo Cancer Center, San Juan, , Puerto Rico
Contact Details
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