Spots Global Cancer Trial Database for Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders

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Trial Identification

Brief Title: Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders

Official Title: Standard of Care Trial: Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders

Study ID: NCT00511537

Conditions

Myeloproliferative Disorders

Interventions

Study Description

Brief Summary: This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.

Detailed Description: This protocol identifies a standard-of-care method for unrelated stem cell transplantation in adults. Performing this service in a consistent and documented fashion allows investigators to obtain informed consent from recipients. Data is tabulated locally for quality-control comparisons with nationally-reported standards. As a condition of maintaining transplant center status and to have acess to NMDP-registered donors, UCSF submits clinical and outcome data to the NMDP. As a result, UCSF is contributing to the resolution of remaining uncertainties regarding particular transplantation practices.