Spots Global Cancer Trial Database for Predictors of Disease Recurrence After Curative Surgery for Stage I Colon Cancer
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Trial Identification
Brief Title: Predictors of Disease Recurrence After Curative Surgery for Stage I Colon Cancer
Official Title: Predictors of Disease Recurrence After Curative Surgery for Stage I Colon Cancer - CORE1 (COlon Cancer REcurrence in Stage 1)
Study ID: NCT05726188
Interventions
Study Description
Brief Summary: Patients with stage I (pT1-2 N0 M0) colon cancer (CC) accounts for 15-20% of colonic neoplasia. Stage I CC is mostly cured with surgical resection, consequently, adjuvant chemotherapy is never considered for this subset of patients. Moreover, some international guidelines, including NCCN guidelines, recommend less intensive follow-up 1. However, around 5% of patients with stage I CC will develop a recurrence within 5 years from surgery. Despite the very good prognosis usually attributed to this stage (5-years relapse-free survival: 95%), some clinical and pathological factors beyond the standard AJCC staging may be associated with worse clinical features and may aid in prognostic stratification. Although some authors investigated the role of pathological and clinical factors in patients with stage II and III disease, only few data are available for patients with stage I CC1. The present multicentric retrospective study aims to: 1. Assess the actual incidence of recurrence in a large cohort of patients with stage I CC undergone curative resection. 2. Investigate the clinical and pathological characteristics of patients who developed a recurrence, with the aim of identifying those associated with a significantly increased risk. 3. Analyze the pattern of recurrence. 4. Analyze survival after recurrence.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Unit of Digestive and HPB Surgery, Henri Mordor University Hospital, Paris, , France
Chirurgia dell'Apparato Digerente, IRCSS Giovanni Paolo II, Bari, , Italy
Chirurgia Generale e Trapianto di Fegato, Azienda Ospedaliera Consorziale Policlinico di Bari, Bari, , Italy
UO Chirurgia Generale 3, Spedali Civili 1, Brescia, , Italy
Chirurgia Coloproctologica, AOU Cagliari, Cagliari, , Italy
Chirurgia Generale, Ospedale di Cles, Cles, , Italy
Chirurgia 1, Ospedale di Cona, AOUI Ferrara, Cona, , Italy
Chirurgia Generale Colorettale, Ospedale degli Infermi, Faenza, , Italy
UOS Chirurgia Colo-rettale, Ospedale San Gerardo, Monza, , Italy
Chirurgia Endoscopica, AOUI Federico II, Napoli, , Italy
UOC Oncologia Chirurgia Colorettale, Istituto Nazionale Tumori - IRCCS Fondazione Pascale, Napoli, , Italy
Chirurgia Generale, AOU San Luigi Gonzaga, Orbassano, , Italy
Chirurgia Generale 3, AOUI Padova, Padova, , Italy
ASL TO 3 Presidio Pinerolo, Chirurgia, Pinerolo, , Italy
Chirurgia Generale 2, Policlinico Gemelli, Roma, , Italy
Policlinico TOR Vergata, Roma, Chirurgia Mininvasiva e dell'Apparato Digerente, Roma, , Italy
UOC Chirurgia Generale 1, Policlinico Gemelli, Roma, , Italy
Chirurgia Generale, Ospedale Santa Maria della Misericordia, Rovigo, , Italy
Chirurgia Colorettale, IRCCS Humanitas, Rozzano, , Italy
Chirurgia d'Urgenza e PS 3, AOU Città della Salute e della Scienza, Torino, , Italy
Chirurgia Generale e Mininvasiva, Ospedale San Camillo, Trento, , Italy
SC Clinica Chirurgia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, , Italy
Unità di Chirurgia Colorettale, Clinica Santa Rita, Vercelli, , Italy
Chirurgia Generale ed Epatobiliare, AOUI Verona, Verona, , Italy
Contact Details
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