Spots Global Cancer Trial Database for Strigolactones and Dysplastic Colonic Lesions or Cancer
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Trial Identification
Brief Title: Strigolactones and Dysplastic Colonic Lesions or Cancer
Official Title: The Effect of the Plant Hormones Strigolactones on Cultures of Dysplastic Colonic Lesions and Cancer
Study ID: NCT02824835
Interventions
Study Description
Brief Summary: The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
Detailed Description: Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Contact Details
Name: Ido Laish, MD
Affiliation: Meir Medical Center
Role: PRINCIPAL_INVESTIGATOR
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