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Spots Global Cancer Trial Database for Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection

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Trial Identification

Brief Title: Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection

Official Title: Efficacy of Segmental Examination Twice of Proximal Colon on Adenoma Detection: a Prospective, Randomized, Controlled Study

Study ID: NCT02581475

Conditions

Colonic Polyps

Study Description

Brief Summary: Segmental examination twice of the proximal colon might be helpful to increase adenoma detection rate (ADR).

Detailed Description: Colonoscopy is the gold standard screening test for colorectal cancer (CRC). Removal of adenomas can reduce the incidence and mortality of CRC. However, there is evidence that some patients may develop interval cancers-cancers developed within 3-5 years following colonoscopy and polypectomy. The overall rate of interval cancer was 1.1-2.7 per 1000 person-years. Several studies have suggested that patients who develop interval cancers are more likely to have proximal compared than distal cancers. One hypothesis is that adenomas may be more likely to be missed in the proximal colon compared with the distal colon. Serrated polyps and some adenomas in the proximal colon may be difficult to detect if they are flat, covered with mucus, or behind folds. A second hypothesis is that neoplastic lesions of the proximal colon may biologically differ from distal lesions and progress to malignancy with a short dwell time. Several tandem back to back colonoscopy studies have demonstrated that up to 27% adenomas in the proximal colon are missed during routine screening colonoscopy. Hover, examining the colon twice as that in the back to back studies is difficult to be performed in clinical practice. Thus, we developed a novel colonoscopy technique, segmental examination twice of the proximal colon, that is simple and easy to be performed. The current study aims to examine the efficacy of segmental examination twice of the proximal colon on adenoma detection rate (ADR) during routine screening and surveillance colonoscopy.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

Contact Details

Name: Yanqing Li, PhD, MD

Affiliation: Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong Province, China

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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