Spots Global Cancer Trial Database for Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence
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Trial Identification
Brief Title: Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence
Official Title: A Randomized, Placebo-controlled, Multicenter, Prospective Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal Adenomas
Study ID: NCT02226185
Conditions
Study Description
Brief Summary: Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored. The aim of this study is to investigate the effect of berberine hydrochloride on the recurrence of colorectal adenomas.
Detailed Description: Colorectal adenomas are well-known to be precancerous lesions that develop into colorectal cancers on the basis of the adenoma-carcinoma sequence. The effects of screening for colorectal adenomas and removing precancerous lesions on the prevention of colorectal cancer have been established. Because of the high recurrence rates of colorectal adenomas in patients who have undergone polypectomy, the potential chemopreventive agents that may reduce the risk of colorectal adenoma recurrence need to be investigated. Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored. The aim of this study is to investigate the effect of berberine hydrochloride on the recurrence of colorectal adenomas by conducting a randomized, placebo-controlled, prospective clinical.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing, Beijing, China
Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China
Department of Gastroenterology, Nanfang Hospital, Southern Medical Univerisity, Guangdong, Guangzhou, China
Division of Gastroenterology and Hepatology, The Affiliated DrumTower of Nanjing University Medical School, Nanjing, Jiangsu, China
Division of Gastroenterology and Hepatology, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Shanghai, Shanghai, China
Department of Gastroenterology, the Shanghai Tenth People's Hospital, Tongji University, Shanghai, Shanghai, China
Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, Tianjin, China
Contact Details
Name: Jing-Yuan Fang, M.D., Ph.D
Affiliation: Shanghai Jiao Tong University School of Medicine
Role: PRINCIPAL_INVESTIGATOR
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