Spots Global Cancer Trial Database for BMS-247550 in Treating Patients With Recurrent or Metastatic Colorectal Cancer
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Trial Identification
Brief Title: BMS-247550 in Treating Patients With Recurrent or Metastatic Colorectal Cancer
Official Title: A Phase II Study Of Epothilone B Analog BMS-247550 (NSC 710428D) In Patients With Advanced Colorectal Carcinoma
Study ID: NCT00022477
Conditions
Interventions
Study Description
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating patients who have recurrent or metastatic colorectal cancer.
Detailed Description: OBJECTIVES: * Determine the objective response rate in patients with locally recurrent or metastatic colorectal cancer treated with BMS-247550. * Determine the toxicity of this drug in these patients. * Determine the duration of response, median and overall survival, and time to progression in patients treated with this drug. OUTLINE: This is a multicenter study. Patients receive BMS-247550 IV over 3 hours on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients are followed every 6 weeks. PROJECTED ACCRUAL: A total of 21-50 patients will be accrued for this study within 8-10 months.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Illinois at Chicago, Chicago, Illinois, United States
University of Chicago Cancer Research Center, Chicago, Illinois, United States
Louis A. Weiss Memorial Hospital, Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States
Evanston Northwestern Health Care, Evanston, Illinois, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
LaGrange Memorial Hospital, LaGrange, Illinois, United States
Loyola University Medical Center, Maywood, Illinois, United States
Lutheran General Cancer Care Center, Park Ridge, Illinois, United States
Oncology/Hematology Associates of Central Illinois, P.C., Peoria, Illinois, United States
Central Illinois Hematology Oncology Center, Springfield, Illinois, United States
Fort Wayne Medical Oncology and Hematology, Inc., Fort Wayne, Indiana, United States
Michiana Hematology/Oncology P.C., South Bend, Indiana, United States
Lakeland Medical Center - St. Joseph, Saint Joseph, Michigan, United States
Albert Einstein Comprehensive Cancer Center, Bronx, New York, United States
Contact Details
Name: Hedy L. Kindler, MD
Affiliation: University of Chicago
Role: STUDY_CHAIR
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