Spots Global Cancer Trial Database for Efficacy and Safety of Olaparib in Pretreated Patients With Measurable Colorectal Cancer, Stratified by Microsatellite Instability (MSI) Status
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Trial Identification
Brief Title: Efficacy and Safety of Olaparib in Pretreated Patients With Measurable Colorectal Cancer, Stratified by Microsatellite Instability (MSI) Status
Official Title: A Phase II, Open-Label, Multicenter Trial to Assess the Efficacy and Safety of the PARP Inhibitor, Olaparib, Alone in Previously-Treated Patients With Stage IV, Measurable Colorectal Cancer, Stratified by MSI Status
Study ID: NCT00912743
Conditions
Interventions
Study Description
Brief Summary: This study is being carried out to see if the new drug, olaparib (AZD2281), can effectively and safely treat advanced large bowel cancer. The primary goal of this clinical trial is to determine whether olaparib will have a beneficial effect on the patient's cancer by causing a response and increasing the time it takes for the cancer to progress.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Los Angeles, California, United States
Research Site, Palm Springs, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Newark, Delaware, United States
Research Site, New York, New York, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Nashville, Tennessee, United States
Research Site, Seattle, Washington, United States
Contact Details
Name: Lawrence P Leichman, MD
Affiliation: Aptium Oncology Gastrointestinal Cancer Consortium
Role: PRINCIPAL_INVESTIGATOR
Name: Bert H O'Neil, MD
Affiliation: Aptium Oncology Gastrointestinal Cancer Consortium
Role: PRINCIPAL_INVESTIGATOR
Name: Jane Robertson, BSc, MBCHB, MD
Affiliation: AstraZeneca
Role: STUDY_DIRECTOR
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