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Spots Global Cancer Trial Database for Fruquintinib Plus FOLFIRI in RAS-mutated Metastatic Colorectal Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Fruquintinib Plus FOLFIRI in RAS-mutated Metastatic Colorectal Cancer

Official Title: The Efficacy and Safety of Fruquintinib Plus FOLFIRI as Second-line Treatment in RAS-mutated Metastatic Colorectal Cancer

Study ID: NCT05842525

Study Description

Brief Summary: RAS mutations are found in nearly half of colorectal cancer patients. However, except for G12C mutation, no driven gene targeted drug can be used. the commonly first-line used treatment regimen is bevacizumab combined with chemotherapy. Angiogenesis is an important therapeutic target in colorectal carcinoma. Fruquintinib is an oral small molecule inhibitor of VEGFR1/2/3, has approved for the third-line treatment of refractory colorectal cancer.

Detailed Description: This is a prospective ,single-center, open labeled, single-arm phase II study exploring the efficacy and safety of fruquintinib combined with FOLFIRI as second-line treatment of RAS-mutated metastatic colorectal cancer (mCRC) in patients with disease progression during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hunan Cancer hospital, Changsha, Hunan, China

Contact Details

Name: zhenyang Liu, MD

Affiliation: Hunan Cancer Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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