Spots Global Cancer Trial Database for Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
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Trial Identification
Brief Title: Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
Official Title: A Randomized Phase III Trial of Three Different Regimens of CPT-11 Plus 5-Fluorouracil and Leucovorin Compared to 5-Fluorouracil and Leucovorin in Patients With Advanced Adenocarcinoma of the Colon and Rectum
Study ID: NCT00003594
Conditions
Study Description
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is most effective in treating advanced colorectal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of various combination chemotherapy regimens in treating patients who have advanced, recurrent, or metastatic colorectal cancer that cannot be treated with surgery or radiation therapy.
Detailed Description: OBJECTIVES: * Compare the time to progression in patients with locally advanced, locally recurrent, or metastatic colorectal adenocarcinoma treated with combinations of oxaliplatin, fluorouracil, leucovorin calcium, and irinotecan. * Compare the quality of life, response rate, time to treatment failure, and overall survival in patients treated with these regimens. * Compare the toxicity of these regimens in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to ECOG performance status (0-1 vs 2), prior adjuvant chemotherapy (yes vs no), prior immunotherapy (yes vs no), and age (under 65 vs 65 and over). Patients are randomized to one of three treatment arms. Only arm II remains open to accrual. * Arm I (Saltz regimen): Patients receive irinotecan IV over 90 minutes followed by leucovorin calcium IV over 15 minutes and fluorouracil IV once a week for 4 weeks followed by 2 weeks of rest. Courses repeat every 6 weeks. (Arm I closed to accrual as of March 15, 2002.) * Arm II (FOLFOX4 regimen): Patients receive oxaliplatin IV over 2 hours on day 1 and leucovorin calcium IV over 2 hours plus fluorouracil IV over 22 hours on days 1 and 2. Courses repeat every 2 weeks. * Arm III (oxaliplatin plus irinotecan): Patients receive oxaliplatin IV over 2 hours and irinotecan IV over 30 minutes on day 1. Courses repeat every 3 weeks. (Arm III closed to accrual as of March 15, 2002.) Treatment continues in the absence of disease progression or unacceptable toxicity. Quality of life is assessed before treatment, during treatment (arm specific), and after completion of treatment. Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 825 patients (275 per arm) have been accrued for this study thus far. Additional patients are being accrued on arm II. (Arms I and III closed to accrual as of March 15, 2002.)
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Veterans Affairs Medical Center - Birmingham, Birmingham, Alabama, United States
MBCCOP - Gulf Coast, Mobile, Alabama, United States
CCOP - Greater Phoenix, Phoenix, Arizona, United States
Veterans Affairs Medical Center - Phoenix (Hayden), Phoenix, Arizona, United States
Mayo Clinic Hospital, Phoenix, Arizona, United States
Mayo Clinic Scottsdale, Scottsdale, Arizona, United States
Veterans Affairs Medical Center - Tucson, Tucson, Arizona, United States
Arizona Cancer Center, Tucson, Arizona, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock, Arkansas, United States
Cancer Center and Beckman Research Institute, City of Hope, Duarte, California, United States
University of California San Diego Cancer Center, La Jolla, California, United States
Veterans Affairs Medical Center - Long Beach, Long Beach, California, United States
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
Veterans Affairs Medical Center - West Los Angeles, Los Angeles, California, United States
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, United States
Community Hospital of the Monterey Peninsula, Monterey, California, United States
CCOP - Bay Area Tumor Institute, Oakland, California, United States
Chao Family Comprehensive Cancer Center, Orange, California, United States
Veterans Affairs Medical Center - Palo Alto, Palo Alto, California, United States
University of California Davis Medical Center, Sacramento, California, United States
Veterans Affairs Medical Center - San Francisco, San Francisco, California, United States
UCSF Cancer Center and Cancer Research Institute, San Francisco, California, United States
CCOP - Santa Rosa Memorial Hospital, Santa Rosa, California, United States
Stanford University Medical Center, Stanford, California, United States
David Grant Medical Center, Travis Air Force Base, California, United States
Columbia Medical Center of Aurora North Campus, Aurora, Colorado, United States
Penrose Cancer Center, Colorado Springs, Colorado, United States
University of Colorado Cancer Center, Denver, Colorado, United States
CCOP - Colorado Cancer Research Program, Inc., Denver, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Presbyterian-St Luke's Medical Center, Denver, Colorado, United States
St. Joseph Hospital, Denver, Colorado, United States
HealthOne Rose Medical Center, Denver, Colorado, United States
Veterans Affairs Medical Center - Denver, Denver, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
Rocky Mountain Cancer Centers - Northern Colorado, Fort Collins, Colorado, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
Poudre Valley Radiation Oncology, Fort Collins, Colorado, United States
St. Mary-Corwin Regional Medical Center, Pueblo, Colorado, United States
Bristol Hospital, Bristol, Connecticut, United States
University of Connecticut Health Center, Farmington, Connecticut, United States
St. Francis Hospital and Medical Center, Hartford, Connecticut, United States
New Britain General Hospital, New Britain, Connecticut, United States
Lawrence and Memorial Hospital, New London, Connecticut, United States
William W. Backus Hospital, Norwich, Connecticut, United States
Northwestern Connecticut Oncology-Hematology Associates, Torrington, Connecticut, United States
CCOP - Christiana Care Health Services, Wilmington, Delaware, United States
Walter Reed Army Medical Center, Washington, District of Columbia, United States
University of Florida - Gainesville, Gainesville, Florida, United States
Baptist Regional Cancer Institute - Jacksonville, Jacksonville, Florida, United States
University of Florida Health Science Center - Jacksonville, Jacksonville, Florida, United States
Mayo Clinic, Jacksonville, Florida, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Emory University Hospital - Atlanta, Atlanta, Georgia, United States
Grady Memorial Hospital, Atlanta, Georgia, United States
CCOP - Atlanta Regional, Atlanta, Georgia, United States
Veterans Affairs Medical Center - Atlanta (Decatur), Decatur, Georgia, United States
Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia, United States
Cancer Research Center of Hawaii, Honolulu, Hawaii, United States
BroMenn Lifecare Center, Bloomington, Illinois, United States
St. Joseph's Hospital Medical Center, Bloomington, Illinois, United States
Graham Hospital Association, Canton, Illinois, United States
Memorial Hospital, Carthage, Illinois, United States
Hematology-Oncology Associates of Illinois, Chicago, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States
Hematology Oncology Associates of Illinois - Lake Shore Dr, Chicago, Illinois, United States
Veterans Affairs Medical Center - Lakeside Chicago, Chicago, Illinois, United States
Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago, Illinois, United States
Mercy Hospital and Medical Center, Chicago, Illinois, United States
University of Chicago Cancer Research Center, Chicago, Illinois, United States
CCOP - Central Illinois, Decatur, Illinois, United States
Holy Family Medical Center, Des Plaines, Illinois, United States
St. Anthony's Memorial Hospital, Effingham, Illinois, United States
Northwest Oncology and Hematology, S.C., Elk Grove Village, Illinois, United States
Eureka Hospital, Eureka, Illinois, United States
CCOP - Evanston, Evanston, Illinois, United States
Galesburg Clinic, Galesburg, Illinois, United States
InterCommunity Cancer Center of Western Illinois, Galesburg, Illinois, United States
Galesburg Cottage Hospital, Galesburg, Illinois, United States
Glenbrook Hospital, Glenview, Illinois, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Mason District Hospital, Havana, Illinois, United States
Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois, United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines, Illinois, United States
Hinsdale Hematology Oncology Associates, Hinsdale, Illinois, United States
Hopedale Medical Complex Hospital, Hopedale, Illinois, United States
Silver Cross Hospital, Joliet, Illinois, United States
Joliet Oncology/Hematology Associates, Ltd., Joliet, Illinois, United States
Saint Joseph Medical Center, Joliet, Illinois, United States
Kewanee Hospital, Kewanee, Illinois, United States
Deerpath Medical Associates, Lake Forest, Illinois, United States
North Shore Oncology Hematology Associates, Libertyville, Illinois, United States
McDonough District Hospital, Macomb, Illinois, United States
Loyola University Medical Center, Maywood, Illinois, United States
Hematology/Oncology Associates of Illinois, LLC, Melrose Park, Illinois, United States
Mendota Community Hospital, Mendota, Illinois, United States
Trinity Medical Center, Moline, Illinois, United States
Morris Hospital, Morris, Illinois, United States
BroMenn Regional Medical Center, Normal, Illinois, United States
Community Cancer Center, Normal, Illinois, United States
Hematology Oncology Associates of Illinois, LLC, Oak Park, Illinois, United States
Community Hospital of Ottawa, Ottawa, Illinois, United States
Pekin Hospital, Pekin, Illinois, United States
Illinois Oncology Research Association, Peoria, Illinois, United States
Oncology/Hematology Associates of Central Illinois, P.C., Peoria, Illinois, United States
Affiliated Urology Specialists, Peoria, Illinois, United States
Midwest Urological Group, Peoria, Illinois, United States
Peoria Urological Associates, Peoria, Illinois, United States
Proctor Hospital, Peoria, Illinois, United States
Methodist Medical Center of Illinois, Peoria, Illinois, United States
Midwest Radiation Oncology Physicians, Peoria, Illinois, United States
St. Francis Medical Center, Peoria, Illinois, United States
Illinois Valley Community Hospital, Peru, Illinois, United States
St. James Hospital, Pontiac, Illinois, United States
Perry Memorial Hospital, Princeton, Illinois, United States
Trinity Medical Center, Rock Island, Illinois, United States
Swedish-American Health System, Rockford, Illinois, United States
Sarah D. Culbertson Memorial Hospital, Rushville, Illinois, United States
Edward H. Kaplan MD and Associates, Skokie, Illinois, United States
Hematology Oncology Associates - Skokie, Skokie, Illinois, United States
Midwest Cancer Research Group, Inc., Skokie, Illinois, United States
St. Margaret's Hospital, Spring Valley, Illinois, United States
Valley Cancer Center, Spring Valley, Illinois, United States
Carle Cancer Center, Urbana, Illinois, United States
Carle Foundation Hospital, Urbana, Illinois, United States
Therapy Associates Hematology/Oncology, Evansville, Indiana, United States
Oncology Institute of Greater Lafayette, Lafayette, Indiana, United States
McFarland Clinic, P.C., Ames, Iowa, United States
William R. Bliss Cancer Center, Ames, Iowa, United States
Hematology Oncology Associates of the Quad Cities, Bettendorf, Iowa, United States
Saint Anthony Regional Hospital, Carroll, Iowa, United States
Cedar Rapids Oncology Associates, Cedar Rapids, Iowa, United States
Mercy Medical Center, Cedar Rapids, Iowa, United States
St. Luke's Hospital, Cedar Rapids, Iowa, United States
Alegent Health Southwest Iowa Medical Center, Council Bluffs, Iowa, United States
Des Moines General Hospital, Des Moines, Iowa, United States
Iowa Methodist Medical Center, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates, Des Moines, Iowa, United States
Mercy Hospital Medical Center, Des Moines, Iowa, United States
Iowa Lutheran Hospital, Des Moines, Iowa, United States
Holden Comprehensive Cancer Center at The University of Iowa, Iowa City, Iowa, United States
Mercy Cancer Center, Mason City, Iowa, United States
Community Memorial Hospital, Missouri Valley, Iowa, United States
Burgess Health Center, Onawa, Iowa, United States
Oncology & Hematology of Ottumwa, PC, Ottumwa, Iowa, United States
Ottumwa Regional Health Center, Ottumwa, Iowa, United States
Siouxland Hematology-Oncology, Sioux City, Iowa, United States
Mercy Medical Center - Sioux City, Sioux City, Iowa, United States
St. Luke's Regional Medical Center, Sioux City, Iowa, United States
Cancer Center of Kansas - Arkansas City, Arkansas City, Kansas, United States
Cancer Center of Kansas - Chanute, Chanute, Kansas, United States
Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States
Radiation Oncology Center, Dodge City, Kansas, United States
Halstead Cancer Center of Kansas, Halstead, Kansas, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
Cancer Center of Kansas - Kingman, Kingman, Kansas, United States
Liberal Cancer Center of Kansas, Liberal, Kansas, United States
Cancer Center of Kansas - Newton, Newton, Kansas, United States
Pratt Cancer Center of Kansas, Pratt, Kansas, United States
Cancer Center of Kansas - Salina, Salina, Kansas, United States
Cancer Center of Kansas - Wellington, Wellington, Kansas, United States
Associates in Women's Health - Wichita, Wichita, Kansas, United States
Wichita Clinic Cancer Medicine Associates, P.A., Wichita, Kansas, United States
CCOP - Wichita, Wichita, Kansas, United States
Cancer Center of Kansas - Wichita, Wichita, Kansas, United States
Via Christi Regional Medical Center, Wichita, Kansas, United States
Veterans Affairs Medical Center - Wichita, Wichita, Kansas, United States
Cancer Center of Kansas - Winfield, Winfield, Kansas, United States
Veterans Affairs Medical Center - Lexington, Lexington, Kentucky, United States
Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, United States
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States
Tulane University School of Medicine, New Orleans, Louisiana, United States
Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States
Veterans Affairs Medical Center - Shreveport, Shreveport, Louisiana, United States
Veterans Affairs Medical Center - Togus, Togus, Maine, United States
Anne Arundel Medical Center, Annapolis, Maryland, United States
New England Medical Center Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Boston Medical Center, Boston, Massachusetts, United States
Faulkner Hospital, Jamaica Plain, Massachusetts, United States
Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain, Massachusetts, United States
Lawrence Memorial Hospital of Medford/Hallmark Health Systems, Medford, Massachusetts, United States
Morton Hospital & Medical Center, Taunton, Massachusetts, United States
University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, United States
Bixby Medical Center, Adrian, Michigan, United States
Veterans Affairs Medical Center - Ann Arbor, Ann Arbor, Michigan, United States
Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Veterans Affairs Medical Center - Detroit, Detroit, Michigan, United States
Henry Ford Hospital, Detroit, Michigan, United States
St. John Hospital and Medical Center, Detroit, Michigan, United States
Genesee Regional Medical Center, Flint, Michigan, United States
CCOP - Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
Sparrow Regional Cancer Center, Lansing, Michigan, United States
Office of E. Michael Lodish, Madison Heights, Michigan, United States
Community Cancer Center of Monroe, Monroe, Michigan, United States
St. Mary's Medical Center, Saginaw, Michigan, United States
Balcueva Clinic, Saginaw, Michigan, United States
Providence Hospital - Southfield, Southfield, Michigan, United States
St. John Macomb Hospital, Warren, Michigan, United States
Alexandria Clinic, Alexandria, Minnesota, United States
Alexandria Radiation Oncology, Alexandria, Minnesota, United States
Brainerd Medical Center, Brainerd, Minnesota, United States
St. Joseph's Medical Center, Brainerd, Minnesota, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy Hospital, Coon Rapids, Minnesota, United States
Duluth Clinic, Duluth, Minnesota, United States
Miller-Dwan Medical Center, Duluth, Minnesota, United States
St. Mary's/Duluth Clinic Health System, Duluth, Minnesota, United States
Fairview-Southdale Hospital, Edina, Minnesota, United States
Fergus Falls Medical Group, Fergus Falls, Minnesota, United States
Mercy/Unity Hospitals, Fridley, Minnesota, United States
Central Mesabi Medical Center, Hibbing, Minnesota, United States
Duluth Clinic - Hibbing, Hibbing, Minnesota, United States
Radiation Therapy Center, Hibbing, Minnesota, United States
Hutchinson Area Health Care, Hutchinson, Minnesota, United States
Meeker County Memorial Hospital, Litchfield, Minnesota, United States
St. John's Hospital, Maplewood, Minnesota, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
Virginia Piper Cancer Institute, Minneapolis, Minnesota, United States
Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States
Veterans Affairs Medical Center - Minneapolis, Minneapolis, Minnesota, United States
North Memorial Research Center, Minneapolis, Minnesota, United States
Fairview University Medical Center - Riverside Campus, Minneapolis, Minnesota, United States
University of Minnesota Cancer Center, Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CentraCare Health Plaza, Saint Cloud, Minnesota, United States
St. Cloud Hospital, Saint Cloud, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Park Nicollet Clinic, Saint Louis Park, Minnesota, United States
Regions Hospital, Saint Paul, Minnesota, United States
Healtheast Cancer Care, Saint Paul, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
Saint Francis Regional Medical Center, Shakopee, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Rice Memorial Hospital, Willmar, Minnesota, United States
Veterans Affairs Medical Center - Biloxi, Biloxi, Mississippi, United States
University of Mississippi Medical Center, Jackson, Mississippi, United States
Veterans Affairs Medical Center - Jackson, Jackson, Mississippi, United States
Keesler Medical Center - Keesler AFB, Keesler Air Force Base, Mississippi, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial), Columbia, Missouri, United States
Ellis Fischel Cancer Center - Columbia, Columbia, Missouri, United States
Veterans Affairs Medical Center - Kansas City, Kansas City, Missouri, United States
CCOP - Kansas City, Kansas City, Missouri, United States
St. Louis University Health Sciences Center, Saint Louis, Missouri, United States
Barnes-Jewish Hospital, Saint Louis, Missouri, United States
CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri, United States
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States
CCOP - Montana Cancer Consortium, Billings, Montana, United States
Fremont Area Medical Center, Fremont, Nebraska, United States
Bryan LGH Medical Center, Lincoln, Nebraska, United States
Prairie View Clinic, Lincoln, Nebraska, United States
Bryan LGH Medical Center East, Lincoln, Nebraska, United States
Office of Susan Hansen, M.D., Lincoln, Nebraska, United States
St. Elizabeth Regional Medical Center, Lincoln, Nebraska, United States
Wedgewood Medical Center, Lincoln, Nebraska, United States
Southeast Nebraska Hematology, Lincoln, Nebraska, United States
Southeast Nebreska Hematology-Oncology Consultants, PC, Lincoln, Nebraska, United States
Williamsburg Radiation Oncology Center, Lincoln, Nebraska, United States
Veterans Affairs Medical Center - Omaha, Omaha, Nebraska, United States
Oncology Hematology West, P.C., Omaha, Nebraska, United States
Alegent Health - Immanuel Medical Center, Omaha, Nebraska, United States
Bergan Mercy Medical Center, Omaha, Nebraska, United States
Creighton University Cancer Center, Omaha, Nebraska, United States
St. Joseph Hospital, Omaha, Nebraska, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
Alegent Health-Midlands Community Hospital, Papillion, Nebraska, United States
CCOP - Southern Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
Norris Cotton Cancer Center, Lebanon, New Hampshire, United States
Center for Cancer And Hematologic Disease, Cherry Hill, New Jersey, United States
Trinitas Hospital - Jersey Street Campus, Elizabeth, New Jersey, United States
Hunterdon Regional Cancer Center, Flemington, New Jersey, United States
South Jersey Regional Cancer Center, Millville, New Jersey, United States
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County, Mount Holly, New Jersey, United States
Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Riverview Medical Center - Booker Cancer Center, Red Bank, New Jersey, United States
St. Francis Medical Center, Trenton, New Jersey, United States
Southern Oncology-Hematology Associates, P.A., Vineland, New Jersey, United States
Comprehensive Cancer and Hematology Associates, Voorhees, New Jersey, United States
Burlington County Hematology Oncology Association, P.A., Willingboro, New Jersey, United States
Veterans Affairs Medical Center - Albuquerque, Albuquerque, New Mexico, United States
MBCCOP - University of New Mexico HSC, Albuquerque, New Mexico, United States
Albert Einstein Comprehensive Cancer Center, Bronx, New York, United States
Veterans Affairs Medical Center - Buffalo, Buffalo, New York, United States
Mary Imogene Bassett Hospital, Cooperstown, New York, United States
CCOP - North Shore University Hospital, Manhasset, New York, United States
Schneider Children's Hospital at North Shore, Manhasset, New York, United States
Veterans Affairs Medical Center - New York, New York, New York, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York, New York, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
New York Presbyterian Hospital - Cornell Campus, New York, New York, United States
Mount Sinai Medical Center, NY, New York, New York, United States
Herbert Irving Comprehensive Cancer Center, New York, New York, United States
Rochester General Hospital, Rochester, New York, United States
State University of New York - Upstate Medical University, Syracuse, New York, United States
Veterans Affairs Medical Center - Syracuse, Syracuse, New York, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse, New York, United States
Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina, United States
Veterans Affairs Medical Center - Durham, Durham, North Carolina, United States
Duke Comprehensive Cancer Center, Durham, North Carolina, United States
CCOP - Southeast Cancer Control Consortium, Winston-Salem, North Carolina, United States
Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States
Bismarck Cancer Center, Bismarck, North Dakota, United States
Medcenter One Health System, Bismarck, North Dakota, United States
Mid Dakota Clinic, P.C., Bismarck, North Dakota, United States
St. Alexius Medical Center, Bismarck, North Dakota, United States
CCOP - Merit Care Hospital, Fargo, North Dakota, United States
Meritcare Roger Maris Cancer Center, Fargo, North Dakota, United States
Altru Health Systems, Grand Forks, North Dakota, United States
Altru Cancer Center, Grand Forks, North Dakota, United States
Akron City Hospital, Akron, Ohio, United States
Wood County Oncology Center, Bowling Green, Ohio, United States
Mercy Ireland Cancer Center, Canton, Ohio, United States
Aultman Cancer Center, Canton, Ohio, United States
Veterans Affairs Medical Center - Cincinnati, Cincinnati, Ohio, United States
Barrett Cancer Center, The University Hospital, Cincinnati, Ohio, United States
Ireland Cancer Center, Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
CCOP - Columbus, Columbus, Ohio, United States
Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, United States
Veterans Affairs Medical Center - Dayton, Dayton, Ohio, United States
Woman Wise Blanchard Valley Regional Health Center, Findlay, Ohio, United States
Fremont Memorial Hospital, Fremont, Ohio, United States
Office of Sharon Cole, M.D., Kenton, Ohio, United States
CCOP - Dayton, Kettering, Ohio, United States
St. Rita's Medical Center, Lima, Ohio, United States
Lima Memorial Hospital, Lima, Ohio, United States
North West Ohio Oncology Center, Maumee, Ohio, United States
Saint Luke's Hospital, Maumee, Ohio, United States
St. Charles Hospital, Oregon, Ohio, United States
Firelands Regional Medical Center, Sandusky, Ohio, United States
North Coast Cancer Care, Inc., Sandusky, Ohio, United States
Flower Hospital - Pro Medica Health System, Sylvania, Ohio, United States
Riverside Hospital, Toledo, Ohio, United States
Toledo Hospital, Toledo, Ohio, United States
St. Vincent Mercy Medical Center, Toledo, Ohio, United States
Medical College of Ohio Hospital, Toledo, Ohio, United States
MCO Cancer Institute, Toledo, Ohio, United States
Haematology-Oncology Associates, Inc., Toledo, Ohio, United States
Toledo Clinic, Inc., Toledo, Ohio, United States
Fulton County Health Center, Wauseon, Ohio, United States
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States
Veterans Affairs Medical Center - Oklahoma City, Oklahoma City, Oklahoma, United States
CCOP - Oklahoma, Tulsa, Oklahoma, United States
Oregon Cancer Center, Portland, Oregon, United States
Veterans Affairs Medical Center - Portland, Portland, Oregon, United States
CCOP - Columbia River Program, Portland, Oregon, United States
Lehigh Valley Hospital, Allentown, Pennsylvania, United States
Muhlenberg Hospital Center, Bethlehem, Pennsylvania, United States
Marion Community Hospital, Carbondale, Pennsylvania, United States
Geisinger Medical Center, Danville, Pennsylvania, United States
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States
DuBois Regional Medical Center, DuBois, Pennsylvania, United States
UPMC Horizon, Greenville, Pennsylvania, United States
Pinnacle Health Hospitals, Harrisburg, Pennsylvania, United States
Wayne Memorial Hospital, Honesdale, Pennsylvania, United States
UPCI @ UPMC Lee Hospital, Johnstown, Pennsylvania, United States
Conemaugh Memorial Hospital, Johnstown, Pennsylvania, United States
Armstrong County Memorial Hospital, Kittanning, Pennsylvania, United States
Lancaster General Hospital, Lancaster, Pennsylvania, United States
Saint Mary Regional Center, Langhorne, Pennsylvania, United States
Latrobe Area Hospital, Latrobe, Pennsylvania, United States
Central Pennsylvania Hematology and Medical Oncology Associates, Lemoyne, Pennsylvania, United States
Hahnemann University Hospital, Philadelphia, Pennsylvania, United States
University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States
Albert Einstein Cancer Center, Philadelphia, Pennsylvania, United States
Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
UPMC/Passavant Hospital, Pittsburgh, Pennsylvania, United States
Pottstown Memorial Regional Cancer Center, Pottstown, Pennsylvania, United States
Reading Hospital and Medical Center, Reading, Pennsylvania, United States
Mercy Hospital Cancer Center - Scranton, Scranton, Pennsylvania, United States
Moses Taylor Hospital, Scranton, Pennsylvania, United States
Scranton Hematology-Oncology, Scranton, Pennsylvania, United States
Geisinger Medical Group, State College, Pennsylvania, United States
Chester County Hospital, West Chester, Pennsylvania, United States
Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
Rhode Island Hospital, Providence, Rhode Island, United States
CCOP - Greenville, Greenville, South Carolina, United States
CCOP - Upstate Carolina, Spartanburg, South Carolina, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
Sioux Valley Clinic, Sioux Falls, South Dakota, United States
Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Sioux Valley Hospital, Sioux Falls, South Dakota, United States
University of Tennessee, Memphis Cancer Center, Memphis, Tennessee, United States
Veterans Affairs Medical Center - Memphis, Memphis, Tennessee, United States
Brooke Army Medical Center, Fort Sam Houston, Texas, United States
University of Texas Medical Branch, Galveston, Texas, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio, Texas, United States
Veterans Affairs Medical Center - Temple, Temple, Texas, United States
CCOP - Scott and White Hospital, Temple, Texas, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Veterans Affairs Medical Center - Salt Lake City, Salt Lake City, Utah, United States
Vermont Cancer Center, Burlington, Vermont, United States
Veterans Affairs Medical Center - White River Junction, White River Junction, Vermont, United States
Veterans Affairs Medical Center - Richmond, Richmond, Virginia, United States
MBCCOP - Massey Cancer Center, Richmond, Virginia, United States
CCOP - Virginia Mason Research Center, Seattle, Washington, United States
Swedish Cancer Institute, Seattle, Washington, United States
Veterans Affairs Medical Center - Seattle, Seattle, Washington, United States
CCOP - Northwest, Tacoma, Washington, United States
Madigan Army Medical Center, Tacoma, Washington, United States
Fox Valley Hematology and Oncology, Appleton, Wisconsin, United States
Memorial Medical Center, Ashland, Wisconsin, United States
Luther Hospital, Eau Claire, Wisconsin, United States
Midelfort Clinic, Eau Claire, Wisconsin, United States
St. Vincent Hospital, Green Bay, Wisconsin, United States
Franciscan Skemp Healthcare, La Crosse, Wisconsin, United States
Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States
Veterans Affairs Medical Center - Madison, Madison, Wisconsin, United States
Dean Medical Center, Madison, Wisconsin, United States
Meriter Hospital, Madison, Wisconsin, United States
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, United States
CCOP - Marshfield Medical Research and Education Foundation, Marshfield, Wisconsin, United States
Aurora Sinai Samaritan Medical Center, Milwaukee, Wisconsin, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee, Wisconsin, United States
Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States
Waukesha Memorial Hospital, Waukesha, Wisconsin, United States
UW Cancer Center Wausau Hospital, Wausau, Wisconsin, United States
Cross Cancer Institute, Edmonton, Alberta, Canada
British Columbia Cancer Agency - Centre for the Southern Interior, Kelowna, British Columbia, Canada
Nanaimo Cancer Clinic, Nanaimo, British Columbia, Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre, Surrey, British Columbia, Canada
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
British Columbia Cancer Agency - Vancouver Island Cancer Centre, Victoria, British Columbia, Canada
St. Boniface General Hospital, Winnipeg, Manitoba, Canada
Nova Scotia Cancer Centre, Halifax, Nova Scotia, Canada
William Osler Health Centre, Brampton, Ontario, Canada
Cancer Care Ontario-London Regional Cancer Centre, London, Ontario, Canada
Trillium Health Centre, Mississauga, Ontario, Canada
Credit Valley Hospital, Mississauga, Ontario, Canada
Southlake Regional Health Centre, Newmarket, Ontario, Canada
Peterborough Oncology Clinic, Peterborough, Ontario, Canada
Algoma District Medical Group, Sault Sainte Marie, Ontario, Canada
Hotel Dieu Health Sciences Hospital - Niagara, St. Catharines, Ontario, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury, Sudbury, Ontario, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay, Thunder Bay, Ontario, Canada
Mount Sinai Hospital - Toronto, Toronto, Ontario, Canada
Saint Joseph's Health Centre - Toronto, Toronto, Ontario, Canada
Humber River Regional Hospital, Weston, Ontario, Canada
Queen Elizabeth Hospital, PEI, Charlottetown, Prince Edward Island, Canada
Hopital Charles Lemoyne, Greenfield Park, Quebec, Canada
Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
CHUM Hopital Saint-Luc, Montreal, Quebec, Canada
L'Hopital Laval, Ste-Foy, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Pasqua Hospital, Regina, Saskatchewan, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada
Lions Gate Hospital, North Vancouver, , Canada
Centro Mamografia Hospital Oncologico, Hato Rey, , Puerto Rico
Veterans Affairs Medical Center - San Juan, San Juan, , Puerto Rico
San Juan City Hospital, San Juan, , Puerto Rico
Medical Oncology Centre of Rosebank, Johannesburg, , South Africa
Pretoria Academic Hospitals, Pretoria, , South Africa
Contact Details
Name: Henry C. Pitot, MD
Affiliation: Mayo Clinic
Role: STUDY_CHAIR
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