Spots Global Cancer Trial Database for Genetic Study in Patients With Stage II or Stage III Colon Cancer
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Trial Identification
Brief Title: Genetic Study in Patients With Stage II or Stage III Colon Cancer
Official Title: The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
Study ID: NCT00003833
Conditions
Study Description
Brief Summary: RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
Detailed Description: OBJECTIVES: * Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer. * Determine if patient prognosis is dependent on the region of 8p AI. * Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. * Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI. OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
St. Mary's/Duluth Clinic Health System, Duluth, Minnesota, United States
Tom Baker Cancer Center - Calgary, Calgary, Alberta, Canada
Lethbridge Cancer Clinic, Lethbridge, Alberta, Canada
Nanaimo Cancer Clinic, Nanaimo, British Columbia, Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre, Surrey, British Columbia, Canada
Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
St. Paul's Hospital - Vancouver, Vancouver, British Columbia, Canada
G. Steinhoff Clinical Research, Victoria, British Columbia, Canada
Moncton Hospital, Moncton, New Brunswick, Canada
Doctor Leon Richard Oncology Centre, Moncton, New Brunswick, Canada
Saint John Regional Hospital, Saint John, New Brunswick, Canada
Newfoundland Cancer Treatment and Research Foundation, St. Johns, Newfoundland and Labrador, Canada
Nova Scotia Cancer Centre, Halifax, Nova Scotia, Canada
Cape Breton Cancer Centre, Sydney, Nova Scotia, Canada
Royal Victoria Hospital, Barrie, Barrie, Ontario, Canada
William Osler Health Centre, Brampton, Ontario, Canada
Hamilton and District Urology Association, Hamilton, Ontario, Canada
London Health Sciences Centre, London, Ontario, Canada
Markham Stouffville Hospital, Markham, Ontario, Canada
Trillium Health Centre, Mississauga, Ontario, Canada
Credit Valley Hospital, Mississauga, Ontario, Canada
York County Hospital, Newmarket, Ontario, Canada
North York General Hospital, Ontario, North York, Ontario, Canada
Male Health Centre/CMX Research Inc., Oakville, Ontario, Canada
Lakeridge Health Oshawa, Oshawa, Ontario, Canada
Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
Peterborough Oncology Clinic, Peterborough, Ontario, Canada
Scarborough Hospital - General Site, Scarborough, Ontario, Canada
Hotel Dieu Health Sciences Hospital - Niagara, St. Catharines, Ontario, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury, Sudbury, Ontario, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay, Thunder Bay, Ontario, Canada
Toronto East General Hospital, Toronto, Ontario, Canada
Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
St. Michael's Hospital - Toronto, Toronto, Ontario, Canada
Mount Sinai Hospital - Toronto, Toronto, Ontario, Canada
Toronto General Hospital, Toronto, Ontario, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
Women's College Campus, Sunnybrook and Women's College Health Science Center, Toronto, Ontario, Canada
Saint Joseph's Health Centre - Toronto, Toronto, Ontario, Canada
Humber River Regional Hospital, Weston, Ontario, Canada
Cancer Care Ontario - Windsor Regional Cancer Centre, Windsor, Ontario, Canada
Queen Elizabeth Hospital, PEI, Charlottetown, Prince Edward Island, Canada
CHUS-Hopital Fleurimont, Fleurimont, Quebec, Canada
Hopital Charles Lemoyne, Greenfield Park, Quebec, Canada
Centre Hospitalier Regional de Lanaudiere, Joliette, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
McGill University, Montreal, Quebec, Canada
Hopital Sainte Justine, Montreal, Quebec, Canada
Hopital Du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
Kells Medical Research Group Inc., Pointe Claire, Quebec, Canada
Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
Hopital du Saint-Sacrament, Quebec, Quebec City, Quebec, Canada
Centre Hospitalier Regional de Rimouski, Rimouski, Quebec, Canada
L'Hopital Laval, Ste-Foy, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada
Lions Gate Hospital, North Vancouver, , Canada
Contact Details
Name: Richard M. Goldberg, MD
Affiliation: Mayo Clinic
Role: STUDY_CHAIR
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