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Brief Title: Genetic Study of Familial Factors in Patients With Colon Cancer
Official Title: Familial Factors in the Development of Colon Cancer
Study ID: NCT00055848
Brief Summary: RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.
Detailed Description: OBJECTIVES: * Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps. * Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients. * Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients. * Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States
Name: Monica M. Bertagnolli, MD
Affiliation: Dana-Farber/Brigham and Women's Cancer Center
Role: STUDY_CHAIR