Spots Global Cancer Trial Database for Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer

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Trial Identification

Brief Title: Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer

Official Title: The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer

Study ID: NCT00467129

Conditions

Colorectal Cancer

Interventions

microarray analysis

mutation analysis

polymerase chain reaction

polymorphism analysis

laboratory biomarker analysis

questionnaire administration

Study Description

Brief Summary: RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and help doctors understand how patients respond to treatment. PURPOSE: This clinical trial is examining genes that affect disease outcome in patients with metastatic colorectal cancer.

Detailed Description: OBJECTIVES: * Collect blood samples for DNA extraction for genetic studies from patients receiving chemotherapy for metastatic colorectal cancer. * Collect detailed clinical, pathological, and chemotherapy data from these patients. * Identify genetic factors that relate to treatment response and outcome in these patients. OUTLINE: Blood samples are collected and relevant genes and regions are amplified by PCR. PCR products are then sequenced or genotyped for known biological markers and single nucleotide polymorphisms. Tumor samples from surplus pathology specimens are analyzed for expression of candidate genes and mutation in the candidate genes. Clinical and family history data is also collected by questionnaire. PROJECTED ACCRUAL: A total of 800 patients will be accrued for this study.