Spots Global Cancer Trial Database for A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal Cancer
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Trial Identification
Brief Title: A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal Cancer
Official Title: A Randomized, Open Label Study of the Effect of First Line Treatment With Xeloda in Combination With Avastin and Either Short Course Irinotecan or Short Course Oxaliplatin on Progression-free Survival in Patients With Metastatic Colorectal Cancer
Study ID: NCT00642603
Conditions
Study Description
Brief Summary: This 2-arm study was designed to evaluate the efficacy and safety of 2 treatment regimens of Xeloda and Avastin, with either irinotecan or oxaliplatin administered for the first 12 cycles, as first line treatment in patients with metastatic colorectal cancer. Patients were randomized to receive 2-weekly cycles of treatment with either: 1) Xeloda, Avastin and oxaliplatin; or 2) Xeloda, Avastin and irinotecan. After 9 cycles, patients continued to receive maintenance treatment with Xeloda + Avastin. The anticipated time on study treatment was until disease progression, and the target sample size was 100-500 individuals.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
, PARK Springs, Arizona, United States
, Sedona, Arizona, United States
, Tucson, Arizona, United States
, Anaheim, California, United States
, Colton, California, United States
, Greenbrae, California, United States
, Loma Linda, California, United States
, Modesto, California, United States
, Montebello, California, United States
, Pomona, California, United States
, Sacramento, California, United States
, Norwich, Connecticut, United States
, Waterbury, Connecticut, United States
, Lake Worth, Florida, United States
, Miami Shores, Florida, United States
, New Port Richey, Florida, United States
, Ocala, Florida, United States
, Ocoee, Florida, United States
, Marietta, Georgia, United States
, Niles, Illinois, United States
, Paducah, Kentucky, United States
, Alexandria, Louisiana, United States
, Baltimore, Maryland, United States
, Baltimore, Maryland, United States
, Westminster, Maryland, United States
, Pittsfield, Massachusetts, United States
, Worcester, Massachusetts, United States
, Kalamazoo, Michigan, United States
, Duluth, Minnesota, United States
, Jefferson City, Missouri, United States
, Great Falls, Montana, United States
, Las Vegas, Nevada, United States
, Neptune, New Jersey, United States
, Albuquerque, New Mexico, United States
, Albuquerque, New Mexico, United States
, Santa Fe, New Mexico, United States
, Brooklyn, New York, United States
, Huntington Station, New York, United States
, Durham, North Carolina, United States
, Hickory, North Carolina, United States
, Canton, Ohio, United States
, Eugene, Oregon, United States
, Ephrata, Pennsylvania, United States
, Langhorne, Pennsylvania, United States
, Philadelphia, Pennsylvania, United States
, Scranton, Pennsylvania, United States
, Charleston, South Carolina, United States
, Charleston, South Carolina, United States
, Florence, South Carolina, United States
, Sumter, South Carolina, United States
, Chattanooga, Tennessee, United States
, Cookeville, Tennessee, United States
, Nashville, Tennessee, United States
, Amarillo, Texas, United States
, Arlington, Texas, United States
, Beaumont, Texas, United States
, Bedford, Texas, United States
, Carrollton, Texas, United States
, Corpus Christi, Texas, United States
, Dallas, Texas, United States
, Dallas, Texas, United States
, Dallas, Texas, United States
, Fort Worth, Texas, United States
, Garland, Texas, United States
, Lewisville, Texas, United States
, Mesquite, Texas, United States
, Paris, Texas, United States
, Round Rock, Texas, United States
, San Antonio, Texas, United States
, Southlake, Texas, United States
, Sugar Land, Texas, United States
, Waco, Texas, United States
, Webster, Texas, United States
, Salt Lake City, Utah, United States
, Christiansburg, Virginia, United States
, Seattle, Washington, United States
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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