Spots Global Cancer Trial Database for The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study

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Trial Identification

Brief Title: The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study

Official Title: The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study

Study ID: NCT04005742

Conditions

Colorectal Cancer

Interventions

Study Description

Brief Summary: Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity. The BORICC Follow-Up (BFU) Study is a 12+ year follow-up of participants recruited to the Biomarkers of Risk of Colon Cancer (BORICC) Study. This longitudinal study will investigate associations between ageing and lifestyle factors and a panel of molecular biomarkers linked with colorectal cancer risk.

Detailed Description: The BORICC Follow-Up (BFU) Study builds on the findings from the BORICC Study where the investigators observed associations between age and nutritional factors, including selenium and folate, and biomarkers of colorectal health. The BFU Study will investigate the relationships between ageing (12+ years) and such biomarkers longitudinally. It is anticipated that the project will produce novel data on (i) changes in biomarkers of colorectal cancer risk with age and (ii) the effects of obesity and lifestyle factors on biomarkers of colorectal cancer risk. These biomarkers include differentially expressed proteins, DNA methylation markers and inflammation markers.