Spots Global Cancer Trial Database for Anesthesia and Postoperative Outcome in Colorectal Cancer Patients

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Trial Identification

Brief Title: Anesthesia and Postoperative Outcome in Colorectal Cancer Patients

Official Title: The Influence of Anesthesia on Postoperative Outcome and Complications in Colorectal Cancer Patients

Study ID: NCT02786329

Conditions

Colorectal Cancer

Interventions

TIVA+lidocaine

Sevoflurane+lidocaine

TIVA+placebo

Sevoflurane+placebo

Study Description

Brief Summary: Study aims to compare the influence of TIVA and sevoflurane anesthesia with or without lidocaine on postoperative short and long term outcome in patients with colorectal cancer undergoing surgery. As short term endpoints postoperative pain and opioid consumption, resumption of bowel function, PONV, LOS will be registered. Long term outcome parameters include: the incidence of chronic pain, 1 and 5 years cancer recurrences incidence and mortality.

Detailed Description: Main goals 1. Comparative evaluation of the incidence of recurrences after TIVA vs sevoflurane anesthesia 2. Evaluation of the effect of lidocaine infusion associated with TIVA/sevoflurane on the incidence of chronic pain and of cancer recurrences and survival. Secondary objectives 1. Evaluation of the influence of lidocaine on postoperative outcome in patients with colorectal cancer 2. Evaluation of the influence of lidocaine on postoperative inflammatory response 3. Evaluation of the influence of lidocaine on the incidence and severity of postoperative pain and outcome in patients with colorectal cancer