Spots Global Cancer Trial Database for Microenvironment and Immunity of Digestive Cancers - East Paris Multicentric Cohort

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Trial Identification

Brief Title: Microenvironment and Immunity of Digestive Cancers - East Paris Multicentric Cohort

Official Title: Interactions Between Tumor, Tumor Microenvironment and Immune System in Digestive Cancers : Impact on Survival and Response to Treatment

Study ID: NCT04707365

Conditions

Colorectal Cancer

Pancreas Tumor

Biliary Tract Tumor

Immune System and Related Disorders

Interventions

Tumor samples

Study Description

Brief Summary: Colorectal and pancreatobiliary cancers are the most common digestive cancers. Their incidence has particularly increased over the last few decades, leading to suspicion that environmental factors are involved. In addition, strategies for the therapeutic management of these cancers are evolving in the context of the development of immunotherapies. Tumor microenvironment is a potential source of new diagnostic, prognostic and predictive markers and new therapeutic targets. The links between tumor microenvironment and modulation of the immune system in colorectal and pancreatobiliary cancers are poorly understood. Molecular classifications have been proposed for these cancers, but their link with immunity and response to treatment remains to be explored. Objective : explore links between molecular subtypes, tumor microenvironment, host (immune system, pre-metastatic niche, intestinal microbiota, metabolism), and survival (prognostic value), response (predictive value) and tolerance (toxicities) to treatments in digestive cancers, in particular colorectal and pancreatobiliary cancers. Method: Retrospective and prospective monocentric cohort study

Detailed Description: