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Brief Title: Screening Platform for Clinical Trials in Advanced Colorectal Cancer
Official Title: Screening Platform of the EORTC for Clinical Trials in Advanced Colorectal Cancer "SPECTAcolor"
Study ID: NCT01723969
Brief Summary: The EORTC GastroIntestinal Tract Cancer Group and the EORTC HeadQuarters wish to set up a European screening platform for advanced colo-rectal cancer (CRC) patients. The goal of this screening platform is to provide quick access to new drugs to patients by offering a new structure for clinical trials. Currently some of the most challenging clinical questions arise from the molecular sub-division of CRC that would theoretically allow to inhibit the specific, altered pathways in the patients. A major problem for trials in this "personalized medicine" is that the low frequency of the different mutations requires a high effort for screening and identifying the patients. The EORTC CRC screening platform will hopefully offer a feasible and efficient way to characterize the patients on the molecular basis of their tumors and allow to offer them rapid and preferential participation in clinical studies with new drugs targeted to their specific pathway alterations.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hopitaux Universitaires Bordet-Erasme - Institut Jules Bordet, Brussels, , Belgium
Hopitaux Universitaires Bordet-Erasme - Hopital Universitaire Erasme, Brussels, , Belgium
Cliniques Universitaires Saint-Luc, Brussels, , Belgium
Universitair Ziekenhuis Antwerpen, Edegem, , Belgium
U.Z. Leuven - Campus Gasthuisberg, Leuven, , Belgium
Bank Of Cyprus Oncology Centre, Stróvolos, , Cyprus
Gustave Roussy Cancer Campus, Villejuif, , France
Universitaetsklinikum Carl Gustav Carus, Dresden, , Germany
Universitaets-Krankenhaus Eppendorf, Hamburg, , Germany
Universitaetsklinikum Leipzig, Leipzig, , Germany
Ludwig-Maximilians-Universitaet Muenchen - Klinikum der Universitaet Muenchen - Campus Grosshadern, Muenchen, , Germany
Kliniken Oldenburg, Oldenburg, , Germany
University General Hospital Heraklion, Heraklion, , Greece
IRCCS Azienda Ospedaliera Universitaria San Martino "IST" Istituto Nazionale per la Ricerca sul Cancro, Genova, , Italy
Seconda Universita Degli Studi Di Napoli, Napoli, , Italy
The Great Poland Cancer Centre, Poznan, , Poland
Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, , Poland
I.P.O. Francisco Gentil - Centro De Lisboa, Lisboa, , Portugal
Hospital General Vall D'Hebron, Barcelona, , Spain
Institut Catala d'Oncologia - ICO L'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat, , Spain
Hospital Universitario San Carlos, Madrid, , Spain
Hospital Universitario 12 De Octubre, Madrid, , Spain
Ostra Sjukhuset, Goteborg, , Sweden
Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie, Geneva, , Switzerland
Centre Hospitalier Universitaire Vaudois, Lausanne, , Switzerland
Hopital du Valais - Hopital de Sion, Sion, , Switzerland
UniversitaetsSpital Zurich, Zurich, , Switzerland
Name: Gunnar Folprecht, MD
Affiliation: Universitaetsklinikum Carl Gustav Carus, Dresden, DE
Role: STUDY_CHAIR
Name: Sabine Tejpar, MD, PhD
Affiliation: U.Z. Leuven - Campus Gasthuisberg, Leuven, BE
Role: STUDY_CHAIR
Name: Daniela Aust, MD
Affiliation: Universitaetsklinikum Carl Gustav Carus, Dresden, DE
Role: STUDY_CHAIR