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Brief Title: An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread
Official Title: A Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Metastatic Colorectal Cancers
Study ID: NCT03377361
Brief Summary: The purpose of this study is to investigate treatment with nivolumab in combination with trametinib with or without ipilimumab in participants with previously treated cancer of the colon or rectum that has spread.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0022, Birmingham, Alabama, United States
Local Institution - 0027, Los Angeles, California, United States
Local Institution - 0067, Los Angeles, California, United States
Local Institution - 0001, San Francisco, California, United States
Local Institution - 0107, Gainesville, Florida, United States
Local Institution - 0111, Miami, Florida, United States
Local Institution - 0028, Baltimore, Maryland, United States
Local Institution - 0116, Hattiesburg, Mississippi, United States
Local Institution - 0103, Saint Louis, Missouri, United States
Local Institution - 0104, New York, New York, United States
Local Institution - 0029, Charlotte, North Carolina, United States
Local Institution - 0100, Lancaster, Pennsylvania, United States
Local Institution - 0003, Philadelphia, Pennsylvania, United States
Thomas Jefferson University - Clinical Research Institute, Philadelphia, Pennsylvania, United States
Local Institution - 0101, Temple, Texas, United States
Local Institution - 0002, Madison, Wisconsin, United States
Local Institution - 0120, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0122, Buenos Aires, Distrito Federal, Argentina
Local Institution - 0123, Ciudad Autónoma de Buenos Aires, Distrito Federal, Argentina
Local Institution - 0119, Buenos Aires, , Argentina
Local Institution - 0044, Blacktown, New South Wales, Australia
Local Institution - 0043, Southport, Queensland, Australia
Local Institution - 0068, Elizabeth Vale, South Australia, Australia
Local Institution - 0055, Clayton, Victoria, Australia
Local Institution - 0069, Heidelberg, Victoria, Australia
Local Institution, Woluwe-Saint-Lambert, , Belgium
Local Institution - 0113, Edmonton, Alberta, Canada
Local Institution - 0070, Toronto, Ontario, Canada
Local Institution - 0077, Montréal, Quebec, Canada
Local Institution - 0076, Ottawa, , Canada
Local Institution - 0117, Santiago, Metropolitana, Chile
Local Institution - 0118, Santiago, Región Metropolitana De Santiago, Chile
Local Institution - 0072, Olomouc, Olomoucký Kraj, Czechia
Local Institution - 0071, Brno, , Czechia
Local Institution - 0073, Hradec Kralove, , Czechia
Local Institution - 0004, Hannover, , Germany
Local Institution - 0095, Catania, , Italy
Local Institution - 0093, Milan, , Italy
Local Institution - 0092, Padova, , Italy
Local Institution - 0094, Rozzano, , Italy
Local Institution - 0079, Badalona, Barcelona [Barcelona], Spain
Local Institution - 0052, Barcelona, , Spain
Local Institution - 0114, Madrid, , Spain
Local Institution - 0051, Madrid, , Spain
Local Institution - 0115, Madrid, , Spain
Local Institution - 0080, Pamplona, , Spain
Local Institution - 0096, Sevilla, , Spain
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR