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Spots Global Cancer Trial Database for β-adrenergic Blocker and a COX2 Inhibitor for Prevention of Colorectal Cancer Recurrence

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Trial Identification

Brief Title: β-adrenergic Blocker and a COX2 Inhibitor for Prevention of Colorectal Cancer Recurrence

Official Title: Perioperative β-adrenergic Blocker and a COX2 Inhibitor in Patients Undergoing Resection for Primary Colon and Rectal Cancer: Effect on Tumor Recurrence and Postoperative Immune Perturbations. A Multicenter Randomized Prospective Trial.

Study ID: NCT00888797

Study Description

Brief Summary: Colon and rectal cancer is the second most prevalent malignant disease in the western world, causing significant morbidity, mortality, and healthcare sources use. Treating colon and rectal cancer with curative intent generally includes resection of the primary tumor. Despite its crucial role, surgery by itself induce physiological changes resulting in significant immune depression and other physiological perturbations, which may in turn play a significant role in the initiation of new metastases and the progression of pre-existing dormant metastases. The aim of this study is to assess the use of perioperative medical intervention using a combination of a β-adrenergic blocker (Propranolol) and a COX2 inhibitor (Etodolac), in order to attenuate the surgically induced immunosuppression and other physiological perturbations, aiming to reduce the rate of tumor recurrence and distant metastatic disease.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Rabin- Beilinson Medical Center, Petah Tikva, , Israel

Tel Aviv-Sourasky Medical Center, Tal Aviv, , Israel

Sheba Medical Center, Tel Hashomer, , Israel

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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