Spots Global Cancer Trial Database for Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)

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Trial Identification

Brief Title: Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)

Official Title: Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.

Study ID: NCT02246634

Conditions

Colorectal Neoplasms

Neoplasm Metastases

Hepatic Neoplasms

Interventions

Diffusion Weighted MRI scan

Study Description

Brief Summary: Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.

Detailed Description: A phase II multicentre, interventional study to determine if additional staging at diagnosis with liver DW-MRI will diagnose more synchronous metastases than CT alone in patients with high risk colorectal cancer. Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local policy.