Spots Global Cancer Trial Database for Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma
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Trial Identification
Brief Title: Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma
Official Title: Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma
Study ID: NCT01500954
Conditions
Interventions
Study Description
Brief Summary: MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.
Detailed Description: Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).
Keywords
Eligibility
Minimum Age: 1 Year
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Bochum, NRW, Germany
Contact Details
Name: Falk G Bechara, PD Dr.
Affiliation: Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum
Role: STUDY_DIRECTOR
Name: Peter Altmeyer, Prof. Dr.
Affiliation: Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum
Role: STUDY_CHAIR
Name: Michael Sand, Dr.
Affiliation: Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum
Role: PRINCIPAL_INVESTIGATOR
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